Hypopigmentary effect of milk thistle extract silymarin = 엉겅퀴 추출물 실리마린의 피부 미백효과

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Hypopigmentary effect of milk thistle extract silymarin = 엉겅퀴 추출물 실리마린의 피부 미백효과
Soo-Jin Choo; In Ja Ryoo; Young Hee Kim; G H Xu; K H Kim; C S Han; S J Kim; J W Kim; E D Son; Ick Dong Yoo
Bibliographic Citation
Journal of Society of Cosmetic Scientists of Korea (Old), vol. 35, no. 2, pp. 151-158
Publication Year
We found that silymarin exhibited the inhibitory effect on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Silymarin is a standardized extract obtained from the dried seeds of milk thistle (Silybum marianum Gaertn.). Silymarin significantly prevented melanin production in a dose-dependent manner with an value of 28.2 without effects on cell viability. Also, silymarin inhibited tyrosinase activity in melanocyte, while it did not affect the catalytic activity of cell-free tyrosinase. Furthermore, Western blot analysis indicated that silymarin decreased the expression of tyrosinase protein. Silybin A/B and isosilybin A/B were also able to inhibit melanin production and tyrosinase expression in protein level. Double blind study on the clinical efficacy of a cream containing 2 % silymarin showed that silymarin have a significant skin whitening effect. Therefore, this study suggests that silymarin may be useful as a natural skin whitening agent.
melanogenesissilymarintyrosinase activitysilybinskin whitening
Korea Soc-Assoc-Inst
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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