Pharmacokinetics of verproside after intravenous and oral administration in rats = rat에서 verproside의 경구 및 혈관투여 후 약동력학 연구

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dc.contributor.authorE J Park-
dc.contributor.authorH S Lee-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorH S Lee-
dc.date.accessioned2017-04-19T09:14:13Z-
dc.date.available2017-04-19T09:14:13Z-
dc.date.issued2009-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-009-1412-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9052-
dc.description.abstractVerproside, a catalpol derivative iridoid glucoside isolated from Pseudolysimachion longifolium, is a candidate for anti-asthmatic drug. The dose-dependency of the pharmacokinetics of verproside was evaluated in rats after intravenous and oral administration. After intravenous administration of verproside (2, 5 and 10 mg/kg doses), the systemic clearance (Cl) was significantly reduced and AUC was significantly increased at 10 mg/kg dose compared to 2 and 5 mg/kg doses. The volume of distribution at steady state (V ss) remained unchanged as the dose was increased. The extent of urinary excretion was low for both intravenous (3.3-6.2%) and oral (0.01-0.04%) doses. Isovanilloylcatalpol was identified as a metabolite after intravenous administration of verproside and showed the significant decreases in AUC and C max at 10 mg/kg verproside dose. The reduced systemic clearance of verproside at high doses appears to be due to the saturable metabolism. Upon oral administration of verproside (20, 50 and 100 mg/kg doses), C max was nonlinearly increased. The extent of verproside recovered from the gastrointestinal tract at 24 h after oral administration was 0.01-0.72% for all three doses studied. The absolute oral bioavailability (F) was 0.3 and 0.5% for 50 and 100 mg/kg doses, respectively. Low F appears to be due to first-pass metabolism.-
dc.publisherPharmaceutical Soc Korea-
dc.titlePharmacokinetics of verproside after intravenous and oral administration in rats = rat에서 verproside의 경구 및 혈관투여 후 약동력학 연구-
dc.title.alternativePharmacokinetics of verproside after intravenous and oral administration in rats-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage564-
dc.citation.startPage559-
dc.citation.volume32-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName박은정-
dc.contributor.alternativeName이현숙-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName이혜숙-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 32, no. 4, pp. 559-564-
dc.identifier.doi10.1007/s12272-009-1412-x-
dc.subject.keywordIsovanilloylcatalpol-
dc.subject.keywordLC/MS-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordRats-
dc.subject.keywordVerproside-
dc.subject.localIsovanilloylcatalpol-
dc.subject.localLC/MS-
dc.subject.localLC-MS-
dc.subject.localpharmacokinetics-
dc.subject.localPharmacokinetics-
dc.subject.localRat-
dc.subject.localrat-
dc.subject.localRats-
dc.subject.localrats-
dc.subject.localRat.-
dc.subject.localverproside-
dc.subject.localVerproside-
dc.description.journalClassY-
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Ochang Branch Institute > 1. Journal Articles
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