Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster

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dc.contributor.authorKyu-Sun Lee-
dc.contributor.authorSeung Hyn Hong-
dc.contributor.authorAe Kyung Kim-
dc.contributor.authorSeong Kyu Joo-
dc.contributor.authorO Y Kwon-
dc.contributor.authorKweon Yu-
dc.date.accessioned2017-04-19T09:14:13Z-
dc.date.available2017-04-19T09:14:13Z-
dc.date.issued2009-
dc.identifier.issn00145793-
dc.identifier.uri10.1016/j.febslet.2009.07.024ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9054-
dc.description.abstractThe Drosophila sNPF gene regulates growth through the ERK-insulin pathway. sNPF encodes a precursor protein that is processed and produces biologically active sNPF peptides. However, the functions of these peptides are not known. In Drosophila neuronal cells in culture and in flies in vivo, sNPF1 and sNPF2 activated the ERK-insulin pathway and regulated body growth. In addition, the sNPF precursor and the processed sNPF peptide were co-localized in the neurons of the central nervous system. These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila.-
dc.publisherWiley-
dc.titleProcessed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster-
dc.title.alternativeProcessed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number15-
dc.citation.endPage2577-
dc.citation.startPage2573-
dc.citation.volume583-
dc.contributor.affiliatedAuthorKyu-Sun Lee-
dc.contributor.affiliatedAuthorAe Kyung Kim-
dc.contributor.affiliatedAuthorKweon Yu-
dc.contributor.alternativeName이규선-
dc.contributor.alternativeName홍승현-
dc.contributor.alternativeName김애경-
dc.contributor.alternativeName주성규-
dc.contributor.alternativeName권오유-
dc.contributor.alternativeName유권-
dc.identifier.bibliographicCitationFEBS Letters, vol. 583, no. 15, pp. 2573-2577-
dc.identifier.doi10.1016/j.febslet.2009.07.024-
dc.subject.keywordDrosophila-
dc.subject.keywordERK-insulin pathway-
dc.subject.keywordGrowth-
dc.subject.keywordProcessed peptide-
dc.subject.keywordShort neuropeptide F-
dc.subject.localDrosophila-
dc.subject.localERK-insulin pathway-
dc.subject.localGrowth-
dc.subject.localProcessed peptide-
dc.subject.localShort neuropeptide F-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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