A genome-wide scan for the sasang constitution in a korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3

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Title
A genome-wide scan for the sasang constitution in a korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3
Author(s)
H H Won; S Lee; E Jang; K K Kim; Y K Park; Young Joo Kim; Yong Sung Kim; B Y Kim; J Y Kim; J W Kim
Bibliographic Citation
Journal of Alternative and Complementary Medicine, vol. 15, no. 7, pp. 765-769
Publication Year
2009
Abstract
Objectives: We aim to identify the genetic loci responsible for Sasang constitution type, which is important for effective personalized treatments in traditional Korean medicine. Subjects: Forty (40) individuals in a Korean family were recruited for linkage analysis and 310 unrelated individuals for association analysis to confirm the linkage result. Outcome measures: Genome-wide linkage analysis was performed for the Korean family using the Affymetrix 500K arrays. MERLIN software was used for multipoint nonparametric linkage (NPL) analysis. The significant candidate regions in linkage analysis were also investigated with association analysis of independent 310 individuals. Results: Linkage analysis showed four significant peaks, 3q27.3, 8p11.21, 8q11.22.23, and 11q22.1.3, whose NPL Z scores are greater than 5.0. Among the significant loci, the 8q11.22.23 and 11q22.1.3 regions were supported by independent association analysis at the level of p<0.05. Conclusions: The 8q11.22.23 and 11q22.1.3 regions were suggested as the candidate region for significant linkage to Sasang constitution.
ISSN
1075-5535
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/acm.2009.0067
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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