DC Field | Value | Language |
---|---|---|
dc.contributor.author | H J Min | - |
dc.contributor.author | Sang Seok Koh | - |
dc.contributor.author | I R Cho | - |
dc.contributor.author | R Srisuttee | - |
dc.contributor.author | E H Park | - |
dc.contributor.author | B H Jhun | - |
dc.contributor.author | Y G Kim | - |
dc.contributor.author | S Oh | - |
dc.contributor.author | J E Kwak | - |
dc.contributor.author | R N Johnston | - |
dc.contributor.author | Y H Chung | - |
dc.date.accessioned | 2017-04-19T09:14:14Z | - |
dc.date.available | 2017-04-19T09:14:14Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | 10.3892/ijo_00000373 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9064 | - |
dc.description.abstract | Reovirus functions as an oncolytic agent for many types of cancer including colon cancer. Although most studies have emphasized the role of activated Ras signaling in enhancing reoviral oncolysis in susceptible cells, we note that many colon cancers also display elevated ß-catenin. Thus, it is possible that enhanced ß-catenin may augment reoviral susceptibility in colon cancer cells. To explore this hypothesis, HEK293 cells were treated with the glycogen synthase kinase (GSK)-3ß inhibitor LiCl, thereby inducing ß-catenin, followed by reoviral infection. Co-administration with LiCl indeed enhanced cell death compared to reovirus infection alone, but this was not associated with elevated reoviral replication. Similarly, HEK293 cells expressing the Frizzled-1 receptor in Wnt3a-conditioned medium also showed reovirus replication equivalent to that in cells in control medium, further suggesting that up-regulation of ß-catenin does not enhance the replication of reovirus. Instead, we observed that inhibition of GSK-3ß with LiCl decreased reovirus-induced NF-κB activation, leading to accelerated apoptosis via ? | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells | - |
dc.title.alternative | Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells | - |
dc.type | Article | - |
dc.citation.title | International Journal of Oncology | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 624 | - |
dc.citation.startPage | 617 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Sang Seok Koh | - |
dc.contributor.alternativeName | 민혜진 | - |
dc.contributor.alternativeName | 고상석 | - |
dc.contributor.alternativeName | 조일래 | - |
dc.contributor.alternativeName | Srisuttee | - |
dc.contributor.alternativeName | 박은희 | - |
dc.contributor.alternativeName | 전병학 | - |
dc.contributor.alternativeName | 김용균 | - |
dc.contributor.alternativeName | 오상택 | - |
dc.contributor.alternativeName | 곽주은 | - |
dc.contributor.alternativeName | Johnston | - |
dc.contributor.alternativeName | 정영화 | - |
dc.identifier.bibliographicCitation | International Journal of Oncology, vol. 35, no. 3, pp. 617-624 | - |
dc.identifier.doi | 10.3892/ijo_00000373 | - |
dc.subject.keyword | reovirus | - |
dc.subject.keyword | glycogen synthase kinase-3ß | - |
dc.subject.keyword | ß-catenin | - |
dc.subject.keyword | nuclear factor-κB | - |
dc.subject.keyword | colon cancer | - |
dc.subject.local | reovirus | - |
dc.subject.local | Reovirus | - |
dc.subject.local | Glycogen synthase kinase 3β | - |
dc.subject.local | glycogen synthase kinase-3ß | - |
dc.subject.local | ß-catenin | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Colon cancer | - |
dc.subject.local | Colon Cancer | - |
dc.subject.local | colon cancer | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.