Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells

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dc.contributor.authorH J Min-
dc.contributor.authorSang Seok Koh-
dc.contributor.authorI R Cho-
dc.contributor.authorR Srisuttee-
dc.contributor.authorE H Park-
dc.contributor.authorB H Jhun-
dc.contributor.authorY G Kim-
dc.contributor.authorS Oh-
dc.contributor.authorJ E Kwak-
dc.contributor.authorR N Johnston-
dc.contributor.authorY H Chung-
dc.date.accessioned2017-04-19T09:14:14Z-
dc.date.available2017-04-19T09:14:14Z-
dc.date.issued2009-
dc.identifier.issn1019-6439-
dc.identifier.uri10.3892/ijo_00000373ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9064-
dc.description.abstractReovirus functions as an oncolytic agent for many types of cancer including colon cancer. Although most studies have emphasized the role of activated Ras signaling in enhancing reoviral oncolysis in susceptible cells, we note that many colon cancers also display elevated ß-catenin. Thus, it is possible that enhanced ß-catenin may augment reoviral susceptibility in colon cancer cells. To explore this hypothesis, HEK293 cells were treated with the glycogen synthase kinase (GSK)-3ß inhibitor LiCl, thereby inducing ß-catenin, followed by reoviral infection. Co-administration with LiCl indeed enhanced cell death compared to reovirus infection alone, but this was not associated with elevated reoviral replication. Similarly, HEK293 cells expressing the Frizzled-1 receptor in Wnt3a-conditioned medium also showed reovirus replication equivalent to that in cells in control medium, further suggesting that up-regulation of ß-catenin does not enhance the replication of reovirus. Instead, we observed that inhibition of GSK-3ß with LiCl decreased reovirus-induced NF-κB activation, leading to accelerated apoptosis via ?-
dc.publisherSpandidos Publ Ltd-
dc.titleInhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells-
dc.title.alternativeInhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells-
dc.typeArticle-
dc.citation.titleInternational Journal of Oncology-
dc.citation.number3-
dc.citation.endPage624-
dc.citation.startPage617-
dc.citation.volume35-
dc.contributor.affiliatedAuthorSang Seok Koh-
dc.contributor.alternativeName민혜진-
dc.contributor.alternativeName고상석-
dc.contributor.alternativeName조일래-
dc.contributor.alternativeNameSrisuttee-
dc.contributor.alternativeName박은희-
dc.contributor.alternativeName전병학-
dc.contributor.alternativeName김용균-
dc.contributor.alternativeName오상택-
dc.contributor.alternativeName곽주은-
dc.contributor.alternativeNameJohnston-
dc.contributor.alternativeName정영화-
dc.identifier.bibliographicCitationInternational Journal of Oncology, vol. 35, no. 3, pp. 617-624-
dc.identifier.doi10.3892/ijo_00000373-
dc.subject.keywordreovirus-
dc.subject.keywordglycogen synthase kinase-3ß-
dc.subject.keywordß-catenin-
dc.subject.keywordnuclear factor-κB-
dc.subject.keywordcolon cancer-
dc.subject.localreovirus-
dc.subject.localReovirus-
dc.subject.localGlycogen synthase kinase 3β-
dc.subject.localglycogen synthase kinase-3ß-
dc.subject.localß-catenin-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localColon cancer-
dc.subject.localColon Cancer-
dc.subject.localcolon cancer-
dc.description.journalClassY-
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