Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition = 꾸지뽕나무 뿌리로 부터 뉴라미니데이즈 제해제 개발

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dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorM J Curtis-Long-
dc.contributor.authorJ W Lee-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorJ Y Kim-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorK H Park-
dc.date.accessioned2017-04-19T09:14:14Z-
dc.date.available2017-04-19T09:14:14Z-
dc.date.issued2009-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2009.07.098ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9065-
dc.description.abstractThe structural characteristics of flavonoids (1.3 and 6.8) from the root of Cudrania tricuspidata required for neuraminidase inhibition were studied and compared with commercially available flavonoids (4, 5, and 9.12). Alkylated flavanones (1.3) display better inhibition than the corresponding parent compound 4. Importantly, flavanone 1 bearing a C-8 hydrated prenyl group showed extremely high inhibition with IC50 of 380 nM. On the other hand, the parent flavone 5 was more effective than alkylated analogues (6.8). Isolated inhibitors (1.3 and 6.8) showed noncompetitive inhibition in kinetic studies. The binding affinity of flavanones (1.4) for neuraminidase in in silico docking experiments correlated well with their IC50 values and noncompetitive inhibition mode.-
dc.publisherElsevier-
dc.titleStructural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition = 꾸지뽕나무 뿌리로 부터 뉴라미니데이즈 제해제 개발-
dc.title.alternativeStructural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number17-
dc.citation.endPage4915-
dc.citation.startPage4912-
dc.citation.volume19-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeNameCurtis-Long-
dc.contributor.alternativeName이지원-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName김준영-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박기훈-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 19, no. 17, pp. 4912-4915-
dc.identifier.doi10.1016/j.bmcl.2009.07.098-
dc.subject.keywordNeuraminidase-
dc.subject.keywordCudrania tricuspidata-
dc.subject.keywordFlavonoid-
dc.subject.localneuraminidase-
dc.subject.localNeuraminidase-
dc.subject.localcudrania tricuspidata-
dc.subject.localCudrania tricuspidata-
dc.subject.localFlavonoids-
dc.subject.localflavonoid-
dc.subject.localflavonoids-
dc.subject.localFlavonoid-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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