CIIA induces the epithelial-mesenchymal transition and cell invasion

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dc.contributor.authorS Y Han-
dc.contributor.authorH S Hwang-
dc.contributor.authorJ S Chae-
dc.contributor.authorYang suk jin-
dc.contributor.authorJ H Yoon-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorE J Choi-
dc.date.accessioned2017-04-19T09:14:16Z-
dc.date.available2017-04-19T09:14:16Z-
dc.date.issued2009-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2009.07.050ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9071-
dc.description.abstractEpithelial.mesenchymal transition (EMT) and the acquisition of invasive potential are key events in tumor progression. We now show that CIIA, originally identified as an anti-apoptotic protein, induces the EMT and promotes cell migration and invasion. Ectopic expression of CIIA induced down-regulation of E-cadherin and claudin-1 as well as up-regulation of N-cadherin in MDCK cells. It also disrupted the differentiated epithelial morphology of MDCK cells grown in three-dimensional Matrigel cultures as well as increased the migration and invasion of MDCK cells in vitro. Furthermore, depletion of endogenous CIIA by RNA interference inhibited the migration and invasion of HeLa cells, and this inhibition was abolished by RNA interference-mediated depletion of claudin-1. These results suggest that CIIA functions as an inducer of cell invasion, and this effect is mediated, at least in part, through down-regulation of claudin-1.-
dc.publisherElsevier-
dc.titleCIIA induces the epithelial-mesenchymal transition and cell invasion-
dc.title.alternativeCIIA induces the epithelial-mesenchymal transition and cell invasion-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number3-
dc.citation.endPage552-
dc.citation.startPage548-
dc.citation.volume387-
dc.contributor.affiliatedAuthorYang suk jin-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName한선영-
dc.contributor.alternativeName황현섭-
dc.contributor.alternativeName채지수-
dc.contributor.alternativeName양석진-
dc.contributor.alternativeName윤제현-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName최의주-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 387, no. 3, pp. 548-552-
dc.identifier.doi10.1016/j.bbrc.2009.07.050-
dc.subject.keywordCIIA-
dc.subject.keywordEpithelial.mesenchymal transition-
dc.subject.keywordMigration-
dc.subject.keywordInvasion-
dc.subject.keywordClaudin-1-
dc.subject.localCIIA-
dc.subject.localEpithelial-mesenchymal transition-
dc.subject.localEpithelial-mesenchymal transition (EMT)-
dc.subject.localEpithelialmesenchymal transition-
dc.subject.localepithelial-mesenchymal transition-
dc.subject.localEpithelial.mesenchymal transition-
dc.subject.localMigration-
dc.subject.localmigration-
dc.subject.localinvasion-
dc.subject.localInvasion-
dc.subject.localClaudin-1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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