DC Field | Value | Language |
---|---|---|
dc.contributor.author | J S Ryu | - |
dc.contributor.author | K Ko | - |
dc.contributor.author | Jeong Woong Lee | - |
dc.contributor.author | S B Park | - |
dc.contributor.author | S J Byun | - |
dc.contributor.author | E J Jeong | - |
dc.contributor.author | K Ko | - |
dc.contributor.author | Y K Choo | - |
dc.date.accessioned | 2017-04-19T09:14:18Z | - |
dc.date.available | 2017-04-19T09:14:18Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2009.07.005 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9073 | - |
dc.description.abstract | Human dental pulp-derived stem cells (hDPSCs) have been considered alternative sources of adult stem cells because of their potential to differentiate into multiple cell lineages. This study investigated the possible role of gangliosides in the neural differentiation of hDPSCs. When hDPSCs were cultured under neural differentiation conditions, expression of neural cell marker genes such as Nestin, MAP-2, and NeuN was detected. Immunostaining and high-performance thin-layer chromatography analysis showed that an increase in ganglioside biosynthesis was associated with neural differentiation of hDPSCs. Specifically, a significant increase in GD3 and GD1a expression was observed during neural differentiation. To confirm the role of gangliosides in neural differentiation, ganglioside biosynthesis was inhibited in hDPSCs by knockdown of UDP-glucose ceramide glucosyltransferase (Ugcg), which prevented differentiation into neural cells. These results suggest that gangliosides may play a role in the neural differentiation process of hDPSCs. | - |
dc.publisher | Elsevier | - |
dc.title | Gangliosides are involved in neural differentiation of human dental pulp-derived stem cells | - |
dc.title.alternative | Gangliosides are involved in neural differentiation of human dental pulp-derived stem cells | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 271 | - |
dc.citation.startPage | 266 | - |
dc.citation.volume | 387 | - |
dc.contributor.affiliatedAuthor | Jeong Woong Lee | - |
dc.contributor.alternativeName | 류재성 | - |
dc.contributor.alternativeName | 고기남 | - |
dc.contributor.alternativeName | 이정웅 | - |
dc.contributor.alternativeName | 박수봉 | - |
dc.contributor.alternativeName | 변성준 | - |
dc.contributor.alternativeName | 정은정 | - |
dc.contributor.alternativeName | 고기성 | - |
dc.contributor.alternativeName | 추용국 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 387, no. 2, pp. 266-271 | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.07.005 | - |
dc.subject.keyword | Gangliosides | - |
dc.subject.keyword | Dental pulp-derived stem cells | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Neuronal differentiation | - |
dc.subject.keyword | Stem cells | - |
dc.subject.local | Ganglioside | - |
dc.subject.local | Gangliosides | - |
dc.subject.local | ganglioside | - |
dc.subject.local | Dental pulp-derived stem cells | - |
dc.subject.local | Mesenchymal stem cell | - |
dc.subject.local | mesenchymal stem cells | - |
dc.subject.local | mesenchymal stem cells (MSCs) | - |
dc.subject.local | Mesenchymal stem cells | - |
dc.subject.local | Neuronal differentiation | - |
dc.subject.local | neuronal differentiation | - |
dc.subject.local | stem cells | - |
dc.subject.local | stem cell | - |
dc.subject.local | Stem cell | - |
dc.subject.local | Stem cells | - |
dc.subject.local | Stem Cell | - |
dc.description.journalClass | Y | - |
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