Gangliosides are involved in neural differentiation of human dental pulp-derived stem cells

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dc.contributor.authorJ S Ryu-
dc.contributor.authorK Ko-
dc.contributor.authorJeong Woong Lee-
dc.contributor.authorS B Park-
dc.contributor.authorS J Byun-
dc.contributor.authorE J Jeong-
dc.contributor.authorK Ko-
dc.contributor.authorY K Choo-
dc.date.accessioned2017-04-19T09:14:18Z-
dc.date.available2017-04-19T09:14:18Z-
dc.date.issued2009-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2009.07.005ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9073-
dc.description.abstractHuman dental pulp-derived stem cells (hDPSCs) have been considered alternative sources of adult stem cells because of their potential to differentiate into multiple cell lineages. This study investigated the possible role of gangliosides in the neural differentiation of hDPSCs. When hDPSCs were cultured under neural differentiation conditions, expression of neural cell marker genes such as Nestin, MAP-2, and NeuN was detected. Immunostaining and high-performance thin-layer chromatography analysis showed that an increase in ganglioside biosynthesis was associated with neural differentiation of hDPSCs. Specifically, a significant increase in GD3 and GD1a expression was observed during neural differentiation. To confirm the role of gangliosides in neural differentiation, ganglioside biosynthesis was inhibited in hDPSCs by knockdown of UDP-glucose ceramide glucosyltransferase (Ugcg), which prevented differentiation into neural cells. These results suggest that gangliosides may play a role in the neural differentiation process of hDPSCs.-
dc.publisherElsevier-
dc.titleGangliosides are involved in neural differentiation of human dental pulp-derived stem cells-
dc.title.alternativeGangliosides are involved in neural differentiation of human dental pulp-derived stem cells-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage271-
dc.citation.startPage266-
dc.citation.volume387-
dc.contributor.affiliatedAuthorJeong Woong Lee-
dc.contributor.alternativeName류재성-
dc.contributor.alternativeName고기남-
dc.contributor.alternativeName이정웅-
dc.contributor.alternativeName박수봉-
dc.contributor.alternativeName변성준-
dc.contributor.alternativeName정은정-
dc.contributor.alternativeName고기성-
dc.contributor.alternativeName추용국-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 387, no. 2, pp. 266-271-
dc.identifier.doi10.1016/j.bbrc.2009.07.005-
dc.subject.keywordGangliosides-
dc.subject.keywordDental pulp-derived stem cells-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordNeuronal differentiation-
dc.subject.keywordStem cells-
dc.subject.localGanglioside-
dc.subject.localGangliosides-
dc.subject.localganglioside-
dc.subject.localDental pulp-derived stem cells-
dc.subject.localMesenchymal stem cell-
dc.subject.localmesenchymal stem cells-
dc.subject.localmesenchymal stem cells (MSCs)-
dc.subject.localMesenchymal stem cells-
dc.subject.localNeuronal differentiation-
dc.subject.localneuronal differentiation-
dc.subject.localstem cells-
dc.subject.localstem cell-
dc.subject.localStem cell-
dc.subject.localStem cells-
dc.subject.localStem Cell-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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