DC Field | Value | Language |
---|---|---|
dc.contributor.author | K H Min | - |
dc.contributor.author | Y Xia | - |
dc.contributor.author | E K Kim | - |
dc.contributor.author | Y Jin | - |
dc.contributor.author | N Kaur | - |
dc.contributor.author | E S Kim | - |
dc.contributor.author | D K Kim | - |
dc.contributor.author | H Y Jung | - |
dc.contributor.author | Y Choi | - |
dc.contributor.author | M K Park | - |
dc.contributor.author | Y K Min | - |
dc.contributor.author | Kiho Lee | - |
dc.contributor.author | Kyeong Lee | - |
dc.date.accessioned | 2017-04-19T09:14:28Z | - |
dc.date.available | 2017-04-19T09:14:28Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2009.07.127 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9082 | - |
dc.description.abstract | Novel disubstituted adamantyl derivatives were synthesized and evaluated in a P-glycoprotein dependent multidrug resistance cancer cell line. The hit to lead optimization provided potent MDR reversal agents. Some potent adamantyl derivatives were more than 10-fold more potent than verapamil without considerable intrinsic cytotoxicity. The 3-trifluorophenyl derivative 14f did not affect the metabolism of CYP450 3A4, whereas most of MDR revertants had a weak inhibitory effect. | - |
dc.publisher | Elsevier | - |
dc.title | A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives | - |
dc.title.alternative | A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 18 | - |
dc.citation.endPage | 5379 | - |
dc.citation.startPage | 5376 | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Kiho Lee | - |
dc.contributor.affiliatedAuthor | Kyeong Lee | - |
dc.contributor.alternativeName | 민경훈 | - |
dc.contributor.alternativeName | Xia | - |
dc.contributor.alternativeName | 김은경 | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | Kaur | - |
dc.contributor.alternativeName | 김은선 | - |
dc.contributor.alternativeName | 김대경 | - |
dc.contributor.alternativeName | 정화영 | - |
dc.contributor.alternativeName | 최용석 | - |
dc.contributor.alternativeName | 박미경 | - |
dc.contributor.alternativeName | 민용기 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.contributor.alternativeName | 이경 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 18, pp. 5376-5379 | - |
dc.identifier.doi | 10.1016/j.bmcl.2009.07.127 | - |
dc.subject.keyword | ABC transporter | - |
dc.subject.keyword | Adamantane | - |
dc.subject.keyword | CYP3A4 | - |
dc.subject.keyword | MES-SA/DX5 | - |
dc.subject.keyword | Multidrug resistance | - |
dc.subject.keyword | P-glycoprotein | - |
dc.subject.local | ABC transporter | - |
dc.subject.local | Adamantane | - |
dc.subject.local | CYP3A4 | - |
dc.subject.local | MES-SA/DX5 | - |
dc.subject.local | multidrug resistance | - |
dc.subject.local | multidrug-resistance (MDR) | - |
dc.subject.local | Multidrug resistance | - |
dc.subject.local | Multidrug-resistance | - |
dc.subject.local | P-glycoprotein | - |
dc.description.journalClass | Y | - |
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