A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives

Cited 15 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorK H Min-
dc.contributor.authorY Xia-
dc.contributor.authorE K Kim-
dc.contributor.authorY Jin-
dc.contributor.authorN Kaur-
dc.contributor.authorE S Kim-
dc.contributor.authorD K Kim-
dc.contributor.authorH Y Jung-
dc.contributor.authorY Choi-
dc.contributor.authorM K Park-
dc.contributor.authorY K Min-
dc.contributor.authorKiho Lee-
dc.contributor.authorKyeong Lee-
dc.date.accessioned2017-04-19T09:14:28Z-
dc.date.available2017-04-19T09:14:28Z-
dc.date.issued2009-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2009.07.127ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9082-
dc.description.abstractNovel disubstituted adamantyl derivatives were synthesized and evaluated in a P-glycoprotein dependent multidrug resistance cancer cell line. The hit to lead optimization provided potent MDR reversal agents. Some potent adamantyl derivatives were more than 10-fold more potent than verapamil without considerable intrinsic cytotoxicity. The 3-trifluorophenyl derivative 14f did not affect the metabolism of CYP450 3A4, whereas most of MDR revertants had a weak inhibitory effect.-
dc.publisherElsevier-
dc.titleA novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives-
dc.title.alternativeA novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number18-
dc.citation.endPage5379-
dc.citation.startPage5376-
dc.citation.volume19-
dc.contributor.affiliatedAuthorKiho Lee-
dc.contributor.affiliatedAuthorKyeong Lee-
dc.contributor.alternativeName민경훈-
dc.contributor.alternativeNameXia-
dc.contributor.alternativeName김은경-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeNameKaur-
dc.contributor.alternativeName김은선-
dc.contributor.alternativeName김대경-
dc.contributor.alternativeName정화영-
dc.contributor.alternativeName최용석-
dc.contributor.alternativeName박미경-
dc.contributor.alternativeName민용기-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName이경-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 19, no. 18, pp. 5376-5379-
dc.identifier.doi10.1016/j.bmcl.2009.07.127-
dc.subject.keywordABC transporter-
dc.subject.keywordAdamantane-
dc.subject.keywordCYP3A4-
dc.subject.keywordMES-SA/DX5-
dc.subject.keywordMultidrug resistance-
dc.subject.keywordP-glycoprotein-
dc.subject.localABC transporter-
dc.subject.localAdamantane-
dc.subject.localCYP3A4-
dc.subject.localMES-SA/DX5-
dc.subject.localmultidrug resistance-
dc.subject.localmultidrug-resistance (MDR)-
dc.subject.localMultidrug resistance-
dc.subject.localMultidrug-resistance-
dc.subject.localP-glycoprotein-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.