The first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group

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dc.contributor.authorS M Ahn-
dc.contributor.authorT H Kim-
dc.contributor.authorSung Hoon Lee-
dc.contributor.authorD Kim-
dc.contributor.authorHoyoung Ghang-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorB C Kim-
dc.contributor.authorSang Yoon Kim-
dc.contributor.authorWoo Yeon Kim-
dc.contributor.authorChulhong Kim-
dc.contributor.authorD Park-
dc.contributor.authorYoung Seok Lee-
dc.contributor.authorS Kim-
dc.contributor.authorR Reja-
dc.contributor.authorSung Woong Cho-
dc.contributor.authorC G Kim-
dc.contributor.authorJ Y Cha-
dc.contributor.authorK H Kim-
dc.contributor.authorB Lee-
dc.contributor.authorJong Hwa Park-
dc.contributor.authorS J Kim-
dc.date.accessioned2017-04-19T09:14:29Z-
dc.date.available2017-04-19T09:14:29Z-
dc.date.issued2009-
dc.identifier.issn1088-9051-
dc.identifier.uri10.1101/gr.092197.109ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9094-
dc.description.abstractWe present the first Korean individual genome sequence (SJK) and analysis results. The diploid genome of a Korean male was sequenced to 28.95-fold redundancy using the Illumina paired-end sequencing method. SJK covered 99.9% of the NCBI human reference genome. We identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in the dbSNP database. Despite a close similarity, significant differences were observed between the Chinese genome (YH), the only other Asian genome available, and SJK: (1) 39.87% (1,371,239 out of 3,439,107) SNPs were SJK-specific (49.51% against Venter's, 46.94% against Watson's, and 44.17% against the Yoruba genomes); (2) 99.5% (22,495 out of 22,605) of short indels (< 4 bp) discovered on the same loci had the same size and type as YH; and (3) 11.3% (331 out of 2920) deletion structural variants were SJK-specific. Even after attempting to map unmapped reads of SJK to unanchored NCBI scaffolds, HGSV, and available personal genomes, there were still 5.77% SJK reads that could not be mapped. All these findings indicate that the overall genetic differences among individuals from closely related ethnic groups may be significant. Hence, constructing reference genomes for minor socio-ethnic groups will be useful for massive individual genome sequencing.-
dc.publisherCold Spring Harbor Lab Press, Publications Dept-
dc.titleThe first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group-
dc.title.alternativeThe first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group-
dc.typeArticle-
dc.citation.titleGenome Research-
dc.citation.number9-
dc.citation.endPage1629-
dc.citation.startPage1622-
dc.citation.volume19-
dc.contributor.affiliatedAuthorSung Hoon Lee-
dc.contributor.affiliatedAuthorHoyoung Ghang-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorSang Yoon Kim-
dc.contributor.affiliatedAuthorWoo Yeon Kim-
dc.contributor.affiliatedAuthorChulhong Kim-
dc.contributor.affiliatedAuthorYoung Seok Lee-
dc.contributor.affiliatedAuthorSung Woong Cho-
dc.contributor.affiliatedAuthorJong Hwa Park-
dc.contributor.alternativeName안성민-
dc.contributor.alternativeName김태형-
dc.contributor.alternativeName이성훈-
dc.contributor.alternativeName김덕훈-
dc.contributor.alternativeName강호영-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName김병철-
dc.contributor.alternativeName김상윤-
dc.contributor.alternativeName김우연-
dc.contributor.alternativeName김철홍-
dc.contributor.alternativeName박대의-
dc.contributor.alternativeName이용석-
dc.contributor.alternativeName김상수-
dc.contributor.alternativeNameReja-
dc.contributor.alternativeName조성웅-
dc.contributor.alternativeName김창근-
dc.contributor.alternativeName차지영-
dc.contributor.alternativeName김경희-
dc.contributor.alternativeName이봉희-
dc.contributor.alternativeName박종화-
dc.contributor.alternativeName김성진-
dc.identifier.bibliographicCitationGenome Research, vol. 19, no. 9, pp. 1622-1629-
dc.identifier.doi10.1101/gr.092197.109-
dc.description.journalClassY-
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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