Glycerol affects the acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus MSl2210

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Title
Glycerol affects the acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus MSl2210
Author(s)
H R Park; Jae Chan Lee; J H Hwang; Dong Jin park; Chang-Jin Kim
Bibliographic Citation
Microbiological Research, vol. 164, no. 4, pp. 588-592
Publication Year
2009
Abstract
Teicoplanin, a glycopeptide antibiotic, is composed of five main components, denoted T-A2-1 to T-A2-5. We investigated the use of glycerol as a carbon source affecting the teicoplanin components and its acyl moieties. As a result, we show the change of teicoplanin components, as well as an increase of total teicoplanin yields, caused by the addition of glycerol to the production medium. Analysis of the total cell lipids upon the addition of glycerol also showed a corresponding change in the proportion of teicoplanin, suggesting that glycerol strongly affects a change of teicoplanin branched acyl moieties.
Keyword
AntibioticCarbon sourceFermentationTeicoplaninAcyl moiety
ISSN
0944-5013
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.micres.2007.05.007
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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