Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta

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dc.contributor.authorM Na-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorH Osada-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:14:31Z-
dc.date.available2017-04-19T09:14:31Z-
dc.date.issued2009-
dc.identifier.issn14756366-
dc.identifier.uri10.1080/14756360802693312ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9100-
dc.description.abstractProtein tyrosine phosphatase 1B (PTP1B) appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. In our preliminary test, a MeOH extract of the stem barks of Sorbus commixta Hedl. (Rosaceae) showed strong PTP1B inhibitory activity. Bioassay-guided fractionation of the MeOH extract resulted in the isolation of two lupane-type triterpenes, lupenone (1) and lupeol (2). Compounds 1 and 2 inhibited PTP1B with IC(50) values of 13.7 +/- 2.1 and 5.6 +/- 0.9 microM, respectively. Kinetic studies revealed that both the compounds 1 and 2 are non-competitive inhibitors of PTP1B that decrease V(max) values with no effect on K(m) values.-
dc.publisherT&F (Taylor & Francis)-
dc.titleInhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta-
dc.title.alternativeInhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta-
dc.typeArticle-
dc.citation.titleJournal of Enzyme Inhibition and Medicinal Chemistry-
dc.citation.number4-
dc.citation.endPage1059-
dc.citation.startPage1056-
dc.citation.volume24-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 4, pp. 1056-1059-
dc.identifier.doi10.1080/14756360802693312-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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