DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y H Kim | - |
dc.contributor.author | H S Kim | - |
dc.contributor.author | J Hwang | - |
dc.contributor.author | J Lee | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | S Y Park | - |
dc.contributor.author | Kyu Tae Chang | - |
dc.contributor.author | K S Kim | - |
dc.contributor.author | Z Y Ryoo | - |
dc.contributor.author | S Lee | - |
dc.date.accessioned | 2017-04-19T09:14:34Z | - |
dc.date.available | 2017-04-19T09:14:34Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | 10.4062/biomolther.2008.16.4.431 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9110 | - |
dc.description.abstract | To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change (≥ 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | A comparison of gene expression profiles between primary human AML cells and therapy-related AML cells | - |
dc.title.alternative | A comparison of gene expression profiles between primary human AML cells and therapy-related AML cells | - |
dc.type | Article | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 436 | - |
dc.citation.startPage | 431 | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Kyu Tae Chang | - |
dc.contributor.alternativeName | 김영훈 | - |
dc.contributor.alternativeName | 김형수 | - |
dc.contributor.alternativeName | 황준모 | - |
dc.contributor.alternativeName | 이진석 | - |
dc.contributor.alternativeName | 김성건 | - |
dc.contributor.alternativeName | 박소영 | - |
dc.contributor.alternativeName | 장규태 | - |
dc.contributor.alternativeName | 김길수 | - |
dc.contributor.alternativeName | 류재영 | - |
dc.contributor.alternativeName | 이상규 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, vol. 16, no. 4, pp. 431-436 | - |
dc.identifier.doi | 10.4062/biomolther.2008.16.4.431 | - |
dc.subject.keyword | Gene expression | - |
dc.subject.keyword | SAGE | - |
dc.subject.keyword | Therapy-related AML | - |
dc.subject.local | Gene Expression | - |
dc.subject.local | Gene expression | - |
dc.subject.local | gene expression | - |
dc.subject.local | SAGE | - |
dc.subject.local | Therapy-related AML | - |
dc.description.journalClass | Y | - |
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