Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity

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Title
Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity
Author(s)
L T K Van; T M Hung; P T Thuong; T M Ngoc; J C Kim; H S Jang; X F Cai; Sei Ryang Oh; B S Min; M H Woo; J S Choi; Hyeong Kyu Lee; K Bea
Bibliographic Citation
Journal of Natural Products, vol. 72, no. 8, pp. 1419-1423
Publication Year
2009
Abstract
The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3α-hydroxyolean-12-en-23,29-dioic acid (1), 3β-hydroxyolean-12-en-23,29-dioic acid (2), 3β,23-dihydroxyolean-12- en-29-oic acid (3), 3R-O-acetylolean-12-en-23,27-dioic acid (4), 3α-O-caffeoylolean-12-en-27-oic acid (5), 3α-O-acetylolean-12-en-23, 29-dioic acid (6), and 3α-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC 50 values of 7.63 and 6.56 μM, respectively.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np900273z
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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