Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis

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dc.contributor.authorJ W Chung-
dc.contributor.authorZ H Piao-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorMi-Sun Kim-
dc.contributor.authorM Jeong-
dc.contributor.authorSuk Hyung Lee-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorY H Cho-
dc.contributor.authorJ C Kim-
dc.contributor.authorJ K Ahn-
dc.contributor.authorK E Kim-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:14:46Z-
dc.date.available2017-04-19T09:14:46Z-
dc.date.issued2009-
dc.identifier.issn15537366-
dc.identifier.uri10.1371/journal.ppat.1000561ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9130-
dc.description.abstractPseudomonas aeruginosa (PA) is an opportunistic pathogen that causes the relapse of illness in immunocompromised patients, leading to prolonged hospitalization, increased medical expense, and death. In this report, we show that PA invades natural killer (NK) cells and induces phagocytosis-induced cell death (PICD) of lymphocytes. In vivo tumor metastasis was augmented by PA infection, with a significant reduction in NK cell number. Adoptive transfer of NK cells mitigated PA-induced metastasis. Internalization of PA into NK cells was observed by transmission electron microscopy. In addition, PA invaded NK cells via phosphoinositide 3-kinase (PI3K) activation, and the phagocytic event led to caspase 9-dependent apoptosis of NK cells. PA-mediated NK cell apoptosis was dependent on activation of mitogen-activated protein (MAP) kinase and the generation of reactive oxygen species (ROS). These data suggest that the phagocytosis of PA by NK cells is a critical event that affects the relapse of diseases in immunocompromised patients, such as those with cancer, and provides important insights into the interactions between PA and NK cells.-
dc.publisherPublic Library of Science-
dc.titlePseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis-
dc.title.alternativePseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis-
dc.typeArticle-
dc.citation.titlePLoS Pathogens-
dc.citation.number8-
dc.citation.endPage1000561-
dc.citation.startPage1000561-
dc.citation.volume5-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName김미선-
dc.contributor.alternativeName정미라-
dc.contributor.alternativeName이석형-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName조유희-
dc.contributor.alternativeName김진철-
dc.contributor.alternativeName안정근-
dc.contributor.alternativeName김균언-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationPLoS Pathogens, vol. 5, no. 8, pp. 1000561-1000561-
dc.identifier.doi10.1371/journal.ppat.1000561-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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