Nanogap biosensors for electrical and label-free detection of biomolecular interactions

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dc.contributor.authorSang Gyu Kim-
dc.contributor.authorHyeon Min Jo-
dc.contributor.authorH J Park-
dc.contributor.authorDo-Hyeong Gwon-
dc.contributor.authorJeong Min Lee-
dc.contributor.authorBong Hyun Chung-
dc.date.accessioned2017-04-19T09:14:49Z-
dc.date.available2017-04-19T09:14:49Z-
dc.date.issued2009-
dc.identifier.issn0957-4484-
dc.identifier.uri10.1088/0957-4484/20/45/455502ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9138-
dc.description.abstractWe demonstrate nanogap biosensors for electrical and label-free detection of biomolecular interactions. Parallel fabrication of nanometer distance gaps has been achieved using a silicon anisotropic wet etching technique on a silicon-on-insulator (SOI) wafer with a finely controllable silicon device layer. Since silicon anisotropic wet etching resulted in a trapezoid-shaped structure whose end became narrower during the etching, the nanogap structure was simply fabricated on the device layer of a SOI wafer. The nanogap devices were individually addressable and a gap size of less than 60nm was obtained. We demonstrate that the nanogap biosensors can electrically detect biomolecular interactions such as biotin/streptavidin and antigen/antibody pairs. The nanogap devices show a current increase when the proteins are bound to the surface. The current increases proportionally depending upon the concentrations of the molecules in the range of 100 fgml-1-100 ngml-1 at 1V bias. It is expected that the nanogap developed here could be a highly sensitive biosensor platform for label-free detection of biomolecular interactions.-
dc.publisherIOP Publishing Ltd-
dc.titleNanogap biosensors for electrical and label-free detection of biomolecular interactions-
dc.title.alternativeNanogap biosensors for electrical and label-free detection of biomolecular interactions-
dc.typeArticle-
dc.citation.titleNanotechnology-
dc.citation.number45-
dc.citation.endPage455508-
dc.citation.startPage455502-
dc.citation.volume20-
dc.contributor.affiliatedAuthorSang Gyu Kim-
dc.contributor.affiliatedAuthorHyeon Min Jo-
dc.contributor.affiliatedAuthorDo-Hyeong Gwon-
dc.contributor.affiliatedAuthorJeong Min Lee-
dc.contributor.affiliatedAuthorBong Hyun Chung-
dc.contributor.alternativeName김상규-
dc.contributor.alternativeName조현민-
dc.contributor.alternativeName박혜정-
dc.contributor.alternativeName권도형-
dc.contributor.alternativeName이정민-
dc.contributor.alternativeName정봉현-
dc.identifier.bibliographicCitationNanotechnology, vol. 20, no. 45, pp. 455502-455508-
dc.identifier.doi10.1088/0957-4484/20/45/455502-
dc.description.journalClassY-
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