DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sang Gyu Kim | - |
dc.contributor.author | Hyeon Min Jo | - |
dc.contributor.author | H J Park | - |
dc.contributor.author | Do-Hyeong Gwon | - |
dc.contributor.author | Jeong Min Lee | - |
dc.contributor.author | Bong Hyun Chung | - |
dc.date.accessioned | 2017-04-19T09:14:49Z | - |
dc.date.available | 2017-04-19T09:14:49Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | 10.1088/0957-4484/20/45/455502 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9138 | - |
dc.description.abstract | We demonstrate nanogap biosensors for electrical and label-free detection of biomolecular interactions. Parallel fabrication of nanometer distance gaps has been achieved using a silicon anisotropic wet etching technique on a silicon-on-insulator (SOI) wafer with a finely controllable silicon device layer. Since silicon anisotropic wet etching resulted in a trapezoid-shaped structure whose end became narrower during the etching, the nanogap structure was simply fabricated on the device layer of a SOI wafer. The nanogap devices were individually addressable and a gap size of less than 60nm was obtained. We demonstrate that the nanogap biosensors can electrically detect biomolecular interactions such as biotin/streptavidin and antigen/antibody pairs. The nanogap devices show a current increase when the proteins are bound to the surface. The current increases proportionally depending upon the concentrations of the molecules in the range of 100 fgml-1-100 ngml-1 at 1V bias. It is expected that the nanogap developed here could be a highly sensitive biosensor platform for label-free detection of biomolecular interactions. | - |
dc.publisher | IOP Publishing Ltd | - |
dc.title | Nanogap biosensors for electrical and label-free detection of biomolecular interactions | - |
dc.title.alternative | Nanogap biosensors for electrical and label-free detection of biomolecular interactions | - |
dc.type | Article | - |
dc.citation.title | Nanotechnology | - |
dc.citation.number | 45 | - |
dc.citation.endPage | 455508 | - |
dc.citation.startPage | 455502 | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Sang Gyu Kim | - |
dc.contributor.affiliatedAuthor | Hyeon Min Jo | - |
dc.contributor.affiliatedAuthor | Do-Hyeong Gwon | - |
dc.contributor.affiliatedAuthor | Jeong Min Lee | - |
dc.contributor.affiliatedAuthor | Bong Hyun Chung | - |
dc.contributor.alternativeName | 김상규 | - |
dc.contributor.alternativeName | 조현민 | - |
dc.contributor.alternativeName | 박혜정 | - |
dc.contributor.alternativeName | 권도형 | - |
dc.contributor.alternativeName | 이정민 | - |
dc.contributor.alternativeName | 정봉현 | - |
dc.identifier.bibliographicCitation | Nanotechnology, vol. 20, no. 45, pp. 455502-455508 | - |
dc.identifier.doi | 10.1088/0957-4484/20/45/455502 | - |
dc.description.journalClass | Y | - |
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