Adipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production

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dc.contributor.authorK Y Kim-
dc.contributor.authorA Baek-
dc.contributor.authorY S Park-
dc.contributor.authorM Y Park-
dc.contributor.authorJ H Kim-
dc.contributor.authorJ S Lim-
dc.contributor.authorM S Lee-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorY Yoon-
dc.contributor.authorD Y Yoon-
dc.contributor.authorY Yang-
dc.date.accessioned2017-04-19T09:14:50Z-
dc.date.available2017-04-19T09:14:50Z-
dc.date.issued2009-
dc.identifier.issn1021-335X-
dc.identifier.uri10.3892/or_00000593ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9142-
dc.description.abstractWe explored whether adipocyte culture medium affects the secreted chemokine profile of tumor cells, because adipocytes stimulate progression or metastasis of breast cancer cells, and chemokines secreted from tumor cells are involved in these processes. CCL20 expression was dramatically increased, and an NF-κB blocker completely inhibited adipocyte culture medium-induced CCL20 expression in MDA-MB-231 cells. We showed that adipocyte culture medium increased the production of TNF-α in MDA-MB-231 cells, which stimulated CCL20 expression in an autocrine fashion. Our data also showed that CCL20 increased the migration and invasiveness of MDA-MB-231 cells, but did not affect the proliferation of these cells.-
dc.publisherSpandidos Publ Ltd-
dc.titleAdipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production-
dc.title.alternativeAdipocyte culture medium stimulates invasiveness of MDA-MB-231 cell via CCL20 production-
dc.typeArticle-
dc.citation.titleOncology Reports-
dc.citation.number6-
dc.citation.endPage1504-
dc.citation.startPage1497-
dc.citation.volume22-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName김건용-
dc.contributor.alternativeName백아미-
dc.contributor.alternativeName박윤선-
dc.contributor.alternativeName박미영-
dc.contributor.alternativeName김재형-
dc.contributor.alternativeName임종석-
dc.contributor.alternativeName이명석-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName윤유식-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName양영-
dc.identifier.bibliographicCitationOncology Reports, vol. 22, no. 6, pp. 1497-1504-
dc.identifier.doi10.3892/or_00000593-
dc.subject.keywordAdipocytes-
dc.subject.keywordBreast cancer-
dc.subject.keywordCCL20-
dc.subject.localAdipocyte-
dc.subject.localadipocyte-
dc.subject.localAdipocytes-
dc.subject.localadipocytes-
dc.subject.localbreast cancer-
dc.subject.localBreast cancer-
dc.subject.localBreast Cancer-
dc.subject.localCCL20-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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