Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca

Cited 14 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorYoung-Hee Kim-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorSoo-Jin Choo-
dc.contributor.authorG H Xu-
dc.contributor.authorSangku Lee-
dc.contributor.authorS J Seok-
dc.contributor.authorK Bae-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T09:14:56Z-
dc.date.available2017-04-19T09:14:56Z-
dc.date.issued2009-
dc.identifier.issn10177825-
dc.identifier.uri10.4014/jmb.0903.03033ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9146-
dc.description.abstractClitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC50 value of 17.8 μM.-
dc.publisherSouth Korea-
dc.titleClitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca-
dc.title.alternativeClitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number10-
dc.citation.endPage1141-
dc.citation.startPage1139-
dc.citation.volume19-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName추수진-
dc.contributor.alternativeNameXu-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName석순자-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 19, no. 10, pp. 1139-1141-
dc.identifier.doi10.4014/jmb.0903.03033-
dc.subject.keywordClitocybe aurantiaca-
dc.subject.keywordClitocybin D-
dc.subject.keywordHuman neutrophil elastase-
dc.subject.localClitocybe aurantiaca-
dc.subject.localClitocybin D-
dc.subject.localHuman neutrophil elastase-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.