DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young-Hee Kim | - |
dc.contributor.author | In Ja Ryoo | - |
dc.contributor.author | Soo-Jin Choo | - |
dc.contributor.author | G H Xu | - |
dc.contributor.author | Sangku Lee | - |
dc.contributor.author | S J Seok | - |
dc.contributor.author | K Bae | - |
dc.contributor.author | Ick Dong Yoo | - |
dc.date.accessioned | 2017-04-19T09:14:56Z | - |
dc.date.available | 2017-04-19T09:14:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | 10.4014/jmb.0903.03033 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9146 | - |
dc.description.abstract | Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC50 value of 17.8 μM. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca | - |
dc.title.alternative | Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca | - |
dc.type | Article | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 1141 | - |
dc.citation.startPage | 1139 | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Young-Hee Kim | - |
dc.contributor.affiliatedAuthor | In Ja Ryoo | - |
dc.contributor.affiliatedAuthor | Soo-Jin Choo | - |
dc.contributor.affiliatedAuthor | Sangku Lee | - |
dc.contributor.affiliatedAuthor | Ick Dong Yoo | - |
dc.contributor.alternativeName | 김영희 | - |
dc.contributor.alternativeName | 류인자 | - |
dc.contributor.alternativeName | 추수진 | - |
dc.contributor.alternativeName | Xu | - |
dc.contributor.alternativeName | 이상구 | - |
dc.contributor.alternativeName | 석순자 | - |
dc.contributor.alternativeName | 배기환 | - |
dc.contributor.alternativeName | 유익동 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, vol. 19, no. 10, pp. 1139-1141 | - |
dc.identifier.doi | 10.4014/jmb.0903.03033 | - |
dc.subject.keyword | Clitocybe aurantiaca | - |
dc.subject.keyword | Clitocybin D | - |
dc.subject.keyword | Human neutrophil elastase | - |
dc.subject.local | clitocybe aurantiaca | - |
dc.subject.local | Clitocybe aurantiaca | - |
dc.subject.local | Clitocybin D | - |
dc.subject.local | Human neutrophil elastase | - |
dc.subject.local | human neutrophil elastase | - |
dc.description.journalClass | Y | - |
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