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- Title
- Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca
- Author(s)
- Young-Hee Kim; In Ja Ryoo; Soo-Jin Choo; G H Xu; Sangku Lee; S J Seok; K Bae; Ick Dong Yoo
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 19, no. 10, pp. 1139-1141
- Publication Year
- 2009
- Abstract
- Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3Hisoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC50 value of 17.8 μM.
- Keyword
- Clitocybe aurantiacaClitocybin DHuman neutrophil elastase
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.4014/jmb.0903.03033
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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