In silico analysis of gene function and transcriptional regulators associated with endoplasmic recticulum (ER) stress = Endoplasmic recticulum stress와 관련된 유전자기능과 전사조절인자의 in silico 분석

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dc.contributor.authorT M Kim-
dc.contributor.authorJ Yeo-
dc.contributor.authorChan Sun Park-
dc.contributor.authorMoon Soo Rhee-
dc.contributor.authorM H Jung-
dc.date.accessioned2017-04-19T09:14:56Z-
dc.date.available2017-04-19T09:14:56Z-
dc.date.issued2009-
dc.identifier.issnI000-0128-
dc.identifier.uri10.5352/JLS.2009.19.8.1159ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9149-
dc.description.abstractIt has been postulated that endoplasmic (ER) stress is involved in the development of several diseases. However, the detailed molecular mechanisms have not been fully understood. Therefore, we characterized a genetic network of genes induced by ER stress using cDNA microarray and gene set expression coherence analysis (GSECA), and identified gene function as well as several transcription regulators associated with ER stress. We analyzed time-dependent gene expression profiles in thapsigargin-treated Sk-Hep1 using an oligonucleotide expression chip, and then selected functional gene sets with significantly high expression coherence which was processed into functional clusters according to the expression similarities. The functions related to sugar binding, lysosome, ribosomal protein, ER lumen, and ER to golgi transport increased, whereas the functions with mRNA processing, DNA replication, DNA repair, cell cycle, electron transport chain and helicase activity decreased. Furthermore, functional clusters were investigated for the enrichment of regulatory motifs using GSECA, and several transcriptional regulators associated with regulation of ER-induced gene expression were found.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleIn silico analysis of gene function and transcriptional regulators associated with endoplasmic recticulum (ER) stress = Endoplasmic recticulum stress와 관련된 유전자기능과 전사조절인자의 in silico 분석-
dc.title.alternativeIn silico analysis of gene function and transcriptional regulators associated with endoplasmic recticulum (ER) stress-
dc.typeArticle-
dc.citation.titleJournal of Life Science-
dc.citation.number8-
dc.citation.endPage1163-
dc.citation.startPage1159-
dc.citation.volume19-
dc.contributor.affiliatedAuthorChan Sun Park-
dc.contributor.affiliatedAuthorMoon Soo Rhee-
dc.contributor.alternativeName김태민-
dc.contributor.alternativeName여지영-
dc.contributor.alternativeName박찬선-
dc.contributor.alternativeName이문수-
dc.contributor.alternativeName정명호-
dc.identifier.bibliographicCitationJournal of Life Science, vol. 19, no. 8, pp. 1159-1163-
dc.identifier.doi10.5352/JLS.2009.19.8.1159-
dc.subject.keywordEndoplasmic recticulum(ER) stress-
dc.subject.keywordgene expression microarray-
dc.subject.keywordgene set expression coherence analysis (GSECA)-
dc.subject.keywordgene function-
dc.subject.keywordtranscription-
dc.subject.keywordtranscription regulator-
dc.subject.localEndoplasmic recticulum(ER) stress-
dc.subject.localgene expression microarray-
dc.subject.localgene set expression coherence analysis (GSECA)-
dc.subject.localgene function-
dc.subject.localGene function-
dc.subject.localTranscription-
dc.subject.localtranscription-
dc.subject.localtranscription regulator-
dc.subject.localTranscription regulator-
dc.description.journalClassN-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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