DC Field | Value | Language |
---|---|---|
dc.contributor.author | H Chon | - |
dc.contributor.author | B Choi | - |
dc.contributor.author | Eun Gyo Lee | - |
dc.contributor.author | Seung-hui Lee | - |
dc.contributor.author | G Jeong | - |
dc.date.accessioned | 2017-04-19T09:14:57Z | - |
dc.date.available | 2017-04-19T09:14:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1364-5072 | - |
dc.identifier.uri | 10.1111/j.1365-2672.2009.04343.x | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9153 | - |
dc.description.abstract | Aims: The objective of this study was to investigate the ability of specific bacterial components of Lactobacillus plantarum KFCC11389P to induce anti-inflammatory mediators in cell cultures of the murine macrophage cell line, RAW 264·7. Methods and Results: The RAW 264·7 cells were stimulated with viable bacterial cells (VC), heat-killed (HK) cells, cell walls (CW) or ultrafiltrates of metabolic products (UF). An increase in the levels of tumour necrosis factor (TNF)-α was observed in VC, HK and CW, but this effect was much lower in UF. VC stimulated higher levels of interleukin (IL)-6 releases as well as nitric oxide production than HK. In contrast, UF and its separated molecule, fraction 4, were much strong IL-10 inducers. Fraction 4 (8·1 kDa), especially, inhibited the production of pro-inflammatory cytokines, IL-6 (89% decrease) and TNF-α (55% decrease), in lipopolysaccharide (LPS)-stimulated murine macrophages. Conclusions: The results of this study indicate that metabolic products of Lact. plantarum KFCC11389P could influence the immune-modulating activity via IL-10, and pretreatment with this specific molecule could inhibit LPS-induced release of IL-6 and TNF-α. Significance and Impact of the Study: Our findings suggest that the specific molecules of Lact. plantarum KFCC11389P may be useful for the treatment of acute inflammatory responses such as Crohn's disease or ulcerative colitis. | - |
dc.publisher | Wiley | - |
dc.title | Immunomodulatory effects of specific bacterial components of Lactobacillus plantarum KFCC11389P on the murine macrophage cell line RAW 264.7 | - |
dc.title.alternative | Immunomodulatory effects of specific bacterial components of Lactobacillus plantarum KFCC11389P on the murine macrophage cell line RAW 264.7 | - |
dc.type | Article | - |
dc.citation.title | Journal of Applied Microbiology | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 1597 | - |
dc.citation.startPage | 1588 | - |
dc.citation.volume | 107 | - |
dc.contributor.affiliatedAuthor | Eun Gyo Lee | - |
dc.contributor.affiliatedAuthor | Seung-hui Lee | - |
dc.contributor.alternativeName | 전희선 | - |
dc.contributor.alternativeName | 최병열 | - |
dc.contributor.alternativeName | 이은교 | - |
dc.contributor.alternativeName | 이승희 | - |
dc.contributor.alternativeName | 정가진 | - |
dc.identifier.bibliographicCitation | Journal of Applied Microbiology, vol. 107, no. 5, pp. 1588-1597 | - |
dc.identifier.doi | 10.1111/j.1365-2672.2009.04343.x | - |
dc.subject.keyword | Anti-inflammation | - |
dc.subject.keyword | Interleukin-10 | - |
dc.subject.keyword | Lactic acid bacteria | - |
dc.subject.keyword | RAW 264·7 cells | - |
dc.subject.local | Anti-inflammation | - |
dc.subject.local | Antiinflammation | - |
dc.subject.local | anti-inflammation | - |
dc.subject.local | Anti-Inflammation | - |
dc.subject.local | antiinflammation | - |
dc.subject.local | Interleukin-10 | - |
dc.subject.local | interleukin-10 | - |
dc.subject.local | Lactic acid bacteria | - |
dc.subject.local | lactic acid bacteria | - |
dc.subject.local | lacti acid bateria | - |
dc.subject.local | RAW 264.7 cells | - |
dc.subject.local | RAW 264·7 cells | - |
dc.description.journalClass | Y | - |
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