Immunomodulatory effects of specific bacterial components of Lactobacillus plantarum KFCC11389P on the murine macrophage cell line RAW 264.7

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dc.contributor.authorH Chon-
dc.contributor.authorB Choi-
dc.contributor.authorEun Gyo Lee-
dc.contributor.authorSeung-hui Lee-
dc.contributor.authorG Jeong-
dc.date.accessioned2017-04-19T09:14:57Z-
dc.date.available2017-04-19T09:14:57Z-
dc.date.issued2009-
dc.identifier.issn1364-5072-
dc.identifier.uri10.1111/j.1365-2672.2009.04343.xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9153-
dc.description.abstractAims: The objective of this study was to investigate the ability of specific bacterial components of Lactobacillus plantarum KFCC11389P to induce anti-inflammatory mediators in cell cultures of the murine macrophage cell line, RAW 264·7. Methods and Results: The RAW 264·7 cells were stimulated with viable bacterial cells (VC), heat-killed (HK) cells, cell walls (CW) or ultrafiltrates of metabolic products (UF). An increase in the levels of tumour necrosis factor (TNF)-α was observed in VC, HK and CW, but this effect was much lower in UF. VC stimulated higher levels of interleukin (IL)-6 releases as well as nitric oxide production than HK. In contrast, UF and its separated molecule, fraction 4, were much strong IL-10 inducers. Fraction 4 (8·1 kDa), especially, inhibited the production of pro-inflammatory cytokines, IL-6 (89% decrease) and TNF-α (55% decrease), in lipopolysaccharide (LPS)-stimulated murine macrophages. Conclusions: The results of this study indicate that metabolic products of Lact. plantarum KFCC11389P could influence the immune-modulating activity via IL-10, and pretreatment with this specific molecule could inhibit LPS-induced release of IL-6 and TNF-α. Significance and Impact of the Study: Our findings suggest that the specific molecules of Lact. plantarum KFCC11389P may be useful for the treatment of acute inflammatory responses such as Crohn's disease or ulcerative colitis.-
dc.publisherWiley-
dc.titleImmunomodulatory effects of specific bacterial components of Lactobacillus plantarum KFCC11389P on the murine macrophage cell line RAW 264.7-
dc.title.alternativeImmunomodulatory effects of specific bacterial components of Lactobacillus plantarum KFCC11389P on the murine macrophage cell line RAW 264.7-
dc.typeArticle-
dc.citation.titleJournal of Applied Microbiology-
dc.citation.number5-
dc.citation.endPage1597-
dc.citation.startPage1588-
dc.citation.volume107-
dc.contributor.affiliatedAuthorEun Gyo Lee-
dc.contributor.affiliatedAuthorSeung-hui Lee-
dc.contributor.alternativeName전희선-
dc.contributor.alternativeName최병열-
dc.contributor.alternativeName이은교-
dc.contributor.alternativeName이승희-
dc.contributor.alternativeName정가진-
dc.identifier.bibliographicCitationJournal of Applied Microbiology, vol. 107, no. 5, pp. 1588-1597-
dc.identifier.doi10.1111/j.1365-2672.2009.04343.x-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordInterleukin-10-
dc.subject.keywordLactic acid bacteria-
dc.subject.keywordRAW 264·7 cells-
dc.subject.localAnti-inflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localantiinflammation-
dc.subject.localInterleukin-10-
dc.subject.localinterleukin-10-
dc.subject.localLactic acid bacteria-
dc.subject.locallactic acid bacteria-
dc.subject.locallacti acid bateria-
dc.subject.localRAW 264.7 cells-
dc.subject.localRAW 264·7 cells-
dc.description.journalClassY-
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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