Viral interferon regulatory factors

Cited 56 time in scopus
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dc.contributor.authorH R Lee-
dc.contributor.authorMyung Hee Kim-
dc.contributor.authorJ S Lee-
dc.contributor.authorC Liang-
dc.contributor.authorJ U Jung-
dc.date.accessioned2017-04-19T09:15:10Z-
dc.date.available2017-04-19T09:15:10Z-
dc.date.issued2009-
dc.identifier.issn10799907-
dc.identifier.uri10.1089/jir.2009.0067.ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9182-
dc.description.abstractUpon viral infection, the major defensive strategy employed by the host immune system is the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN regulatory factors (IRFs). In order to complete their life cycles, viruses must find a way to modulate the host IFN-mediated immune response. Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor-inducing herpesvirus, has developed a unique mechanism for antagonizing cellular IFN-mediated antiviral activity by incorporating viral homolog of the cellular IRFs, called vIRFs, into its genome. Here, we summarize the novel evasion mechanisms by which KSHV, through its vIRFs, circumvents IFN-mediated innate immune responses and deregulates the cell growth control mechanism.-
dc.publisherMary Ann Liebert, Inc-
dc.titleViral interferon regulatory factors-
dc.title.alternativeViral interferon regulatory factors-
dc.typeArticle-
dc.citation.titleJournal of Interferon and Cytokine Research-
dc.citation.number9-
dc.citation.endPage627-
dc.citation.startPage621-
dc.citation.volume29-
dc.contributor.affiliatedAuthorMyung Hee Kim-
dc.contributor.alternativeName이혜라-
dc.contributor.alternativeName김명희-
dc.contributor.alternativeName이종수-
dc.contributor.alternativeNameLiang-
dc.contributor.alternativeName정재-
dc.identifier.bibliographicCitationJournal of Interferon and Cytokine Research, vol. 29, no. 9, pp. 621-627-
dc.identifier.doi10.1089/jir.2009.0067-
dc.description.journalClassY-
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Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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