Genome evolution and adaptation in a long-term experiment with Escherichia coli

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dc.contributor.authorJ E Barrick-
dc.contributor.authorDong Su Yu-
dc.contributor.authorSung Ho Yoon-
dc.contributor.authorHaeyoung Jeong-
dc.contributor.authorTae Kwang Oh-
dc.contributor.authorD Schneider-
dc.contributor.authorR E Lenski-
dc.contributor.authorJihyun Kim-
dc.date.accessioned2017-04-19T09:15:12Z-
dc.date.available2017-04-19T09:15:12Z-
dc.date.issued2009-
dc.identifier.issn00280836-
dc.identifier.uri10.1038/nature08480ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9187-
dc.description.abstractThe relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable.-
dc.publisherSpringer-Nature Pub Group-
dc.titleGenome evolution and adaptation in a long-term experiment with Escherichia coli-
dc.title.alternativeGenome evolution and adaptation in a long-term experiment with Escherichia coli-
dc.typeArticle-
dc.citation.titleNature-
dc.citation.number7268-
dc.citation.endPage1247-
dc.citation.startPage1243-
dc.citation.volume461-
dc.contributor.affiliatedAuthorHaeyoung Jeong-
dc.contributor.affiliatedAuthorTae Kwang Oh-
dc.contributor.alternativeNameBarrick-
dc.contributor.alternativeName유동수-
dc.contributor.alternativeName윤성호-
dc.contributor.alternativeName정해영-
dc.contributor.alternativeName오태광-
dc.contributor.alternativeNameSchneider-
dc.contributor.alternativeNameLenski-
dc.contributor.alternativeName김지현-
dc.identifier.bibliographicCitationNature, vol. 461, no. 7268, pp. 1243-1247-
dc.identifier.doi10.1038/nature08480-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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