Rhodiosin, an antioxidant flavonol glycoside from Rhodiola rosea = 홍경천뿌리로부터 항산화제인 플라보노이드화합물인 로디오신의 개발

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Title
Rhodiosin, an antioxidant flavonol glycoside from Rhodiola rosea = 홍경천뿌리로부터 항산화제인 플라보노이드화합물인 로디오신의 개발
Author(s)
Hyung Jun KwonYoung Bae RyuHyung Jae Jung; Jang Hun Kim; Su-Jin Park; Jong Sun Chang; Min-Soo KimMun Chual RhoWoo Song Lee
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 52, no. 5, pp. 486-492
Publication Year
2009
Abstract
The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with IC50 values of 0.21 and 0.15 μM against .OH and .O- 2, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of γ-radiation.
Keyword
antioxidantγ-irradiationRhodiola roseaRhodiosinUWLA
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3839/jksabc.2009.083
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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