Two lignans from the stem bark of Styrax japonica

Abstract

Two lignans, 1R,2R,5S,6R-2-(4′-hydroxy-3′-methoxyphenyl)-6-(3′’,4′’-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane 4′-O-β-D-glucopyranoside (1) and styraxlignolides F (2), were isolated from the EtOAc-soluble fraction of the stem bark of Styrax japonica (Styracaceae). The structures of lignans (1-2) were determined by spectroscopic means. The absolute configuration for styraxlignolides F (2), (2S,3S)-2-(3′’,4′’-dimethoxybenzyl)-3-(4′-hydroxy-3′-methoxybenzyl)-γ-butyrolactone 4′-O-(β-D-glucopyranoside), was unambiguously confirmed by X-ray diffraction analysis.