A Near-Infrared Fluorescence-Based Optical Thermosensor

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Title
A Near-Infrared Fluorescence-Based Optical Thermosensor
Author(s)
S Y Lee; S Lee; I C Youn; D K Yi; Y T Lim; Bong Hyun Chung; J F Leary; I C Kwon; K Kim; K Choi
Bibliographic Citation
Chemistry-A European Journal, vol. 15, no. 25, pp. 6103-6106
Publication Year
2009
Abstract
A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.
Keyword
AggregationImaging agentsMicellesSensors
ISSN
0947-6539
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/chem.200900683
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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