Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611 = Sporothrix sp. FN611 균주가 생산하는 새로운 enoyl-acyl carrier protein reductase 저해제 Aquastatin A

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dc.contributor.authorYun Ju Kwon-
dc.contributor.authorY Fang-
dc.contributor.authorG H Xu-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:15:39Z-
dc.date.available2017-04-19T09:15:39Z-
dc.date.issued2009-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.32.2061ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9252-
dc.description.abstractBacterial enoyl-acyl carrier protein (ACP) reductase has been confirmed as a novel target for antibacterial drug development. In this study, we determined that a fungal metabolite from Sporothrix sp. FN611 potently inhibited the enoyl-ACP reductase (FabI) of Staphylococcus aureus. Its structure identified the metabolite as aquastatin A by the MS and NMR data. Aquastatin A inhibited S. aureus FabI with an IC50 of 3.2 μM. It also prevented the growth of S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration of 16-32 μg/ml. Aquastatin A also exerted an inhibitory effect against the FabK isoform, an enoyl-ACP reductase of Streptococcus pneumoniae, with an IC50 of 9.2 μM. The degalactosylation of aquastatin A did not affect the FabI and FabK-inhibitory or antibacterial activities, thereby suggesting that the sugar moiety within its molecular structure was not involved in these activities. The inhibitory effects of aquastatin A and its degalactosylated derivative on enoyl-ACP reductases and bacterial viability are reported for the first time in this study; these effects point to the potential that aquastatin A may be developed into a new broad-spectrum antibacterial and anti-MRSA agent.-
dc.publisherPharmaceutical Soc Japan-
dc.titleAquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611 = Sporothrix sp. FN611 균주가 생산하는 새로운 enoyl-acyl carrier protein reductase 저해제 Aquastatin A-
dc.title.alternativeAquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number12-
dc.citation.endPage2064-
dc.citation.startPage2061-
dc.citation.volume32-
dc.contributor.affiliatedAuthorYun Ju Kwon-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName권윤주-
dc.contributor.alternativeNameFang-
dc.contributor.alternativeNameXu-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 32, no. 12, pp. 2061-2064-
dc.identifier.doi10.1248/bpb.32.2061-
dc.subject.keywordAquastatin A-
dc.subject.keywordEnoyl-acyl carrier protein reductase-
dc.subject.keywordFabI-
dc.subject.keywordFungal metabolite-
dc.subject.keywordInhibitor-
dc.subject.keywordStaphylococcus aureus-
dc.subject.localAquastatin A-
dc.subject.localEnoyl-acyl carrier protein reductase-
dc.subject.localFabI-
dc.subject.localfungal metabolite-
dc.subject.localFungal metabolite-
dc.subject.localinhibitors-
dc.subject.localInhibitors-
dc.subject.localinhibitor-
dc.subject.localInhibitor-
dc.subject.localStaphylococcus aureus-
dc.subject.localstaphylococcus aureus-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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