Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060

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dc.contributor.authorC Seo-
dc.contributor.authorJ H Sohn-
dc.contributor.authorH Oh-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:15:39Z-
dc.date.available2017-04-19T09:15:39Z-
dc.date.issued2009-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2009.09.025ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9254-
dc.description.abstractIn the course of bioassay-guided study on the EtOAc extract of a culture broth of the marine-derived fungus Cosmospora sp. SF-5060, aquastatin A (1) was isolated as a protein tyrosine phosphatase 1B (PTP1B) inhibitory component produced by the fungus. The compound was isolated by various chromatographic methods, and the structure was determined mainly by analysis of NMR spectroscopic data. Compound 1 exhibited potent inhibitory activity against PTP1B with IC50 value of 0.19 μM, and the kinetic analyses of PTP1B inhibition by compound 1 suggested that the compound is inhibiting PTP1B activity in a competitive manner. Aquastatin A (1) also showed modest but selective inhibitory activity toward PTP1B over other protein tyrosine phosphatases, such as TCPTP, SHP-2, LAR, and CD45. In addition, the result of hydrolyzing aquastatin A (1) suggested that the dihydroxypentadecyl benzoic acid moiety in the molecule is responsible for the inhibitory activity.-
dc.publisherElsevier-
dc.titleIsolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060-
dc.title.alternativeIsolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number21-
dc.citation.endPage6097-
dc.citation.startPage6095-
dc.citation.volume19-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName서찬건-
dc.contributor.alternativeName손재학-
dc.contributor.alternativeName오현철-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 19, no. 21, pp. 6095-6097-
dc.identifier.doi10.1016/j.bmcl.2009.09.025-
dc.subject.keywordCompetitive inhibitor-
dc.subject.keywordCosmospora sp.-
dc.subject.keywordFungal metabolite-
dc.subject.keywordMarine-derived fungus-
dc.subject.keywordProtein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localcompetitive inhibitor-
dc.subject.localCompetitive inhibitor-
dc.subject.localCosmospora sp.-
dc.subject.localfungal metabolite-
dc.subject.localFungal metabolite-
dc.subject.localmarine-derived fungus-
dc.subject.localMarine-derived fungus-
dc.subject.localprotein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase-1B (PTP1B)-
dc.subject.localProtein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localprotein tyrosine phosphatase 1B (FTPIB)-
dc.subject.localProtein tyrosine phosphatase 1B (PTP1B)-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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