Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production

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dc.contributor.authorY S Choi-
dc.contributor.authorH J Choi-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorB J Pyun-
dc.contributor.authorY S Maeng-
dc.contributor.authorH Park-
dc.contributor.authorJ Kim-
dc.contributor.authorY M Kim-
dc.contributor.authorY G Kwon-
dc.date.accessioned2017-04-19T09:15:43Z-
dc.date.available2017-04-19T09:15:43Z-
dc.date.issued2009-
dc.identifier.issn0006-4971-
dc.identifier.uri10.1182/blood-2009-02-203372ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9268-
dc.description.abstractInterleukin-33 (IL-33), a member of the IL-1 cytokine family, is emerging as a new regulator of immune responses and inflammatory vascular diseases. Although IL-33 and its cognate receptor ST2 appear to be expressed in vascular cells, the precise role of IL-33 in the vasculature has not been determined. In this study, we report a novel role of IL-33 as a potent endothelial activator, promoting both angiogenesis and vascular permeability. IL-33 increased proliferation, migration, and morphologic differentiation of human endothelial cells, consistently with increased angiogenesis in vivo. IL-33 also increased endothelial permeability with reduced vascular endothelial-cadherin-facilitated cell-cell junctions in vitro and induced vascular leakage in mouse skin. These effects of IL-33 were blocked by knockdown of ST2. Ligation of IL-33 with ST2 rapidly increased endothelial nitric oxide (NO) production through TRAF6-mediated activation of phosphoinoside-3-kinase, Akt, and endothelial NO synthase. Moreover, pharmacologic or genetic blockage of endothelial NO generation resulted in the inhibition of angiogenesis and vascular hyperpermeability induced by IL-33. These data demonstrate that IL-33 promotes angiogenesis and vascular leakage by stimulating endothelial NO production via the ST2/TRAF6-Akt-eNOS signaling pathway. These findings open new perspectives for the role of IL-33 in the pathogenesis of angiogenesis-dependent and inflammatory vascular diseases.-
dc.publisherAmer Soc Hematology-
dc.titleInterleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production-
dc.title.alternativeInterleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production-
dc.typeArticle-
dc.citation.titleBlood-
dc.citation.number14-
dc.citation.endPage3126-
dc.citation.startPage3117-
dc.citation.volume114-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.alternativeName최연숙-
dc.contributor.alternativeName최현정-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName변보정-
dc.contributor.alternativeName맹용선-
dc.contributor.alternativeName박홍렬-
dc.contributor.alternativeName김지혜-
dc.contributor.alternativeName김영명-
dc.contributor.alternativeName권영근-
dc.identifier.bibliographicCitationBlood, vol. 114, no. 14, pp. 3117-3126-
dc.identifier.doi10.1182/blood-2009-02-203372-
dc.description.journalClassY-
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Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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