Mapping human genetic diversity in asia = 인류의 유전적다양성 지도

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Title
Mapping human genetic diversity in asia = 인류의 유전적다양성 지도
Author(s)
M A Abdulla; I Ahmed; A Assawamakin; J Bhak; S K Brahmachari; G C Calacal; Hoyoung Ghang; L Jin; J Jung; H L Kim; K Kim; S Kim; Woo Yeon Kim; K Kimm; J Y Lee; Sung Hoon Lee; E T Liu; Sang Ho Oh; M Seielstad; S Xu; Jin Ok Yang; Hyang Sook Yoo; B A Zilfalil; Indian Genome Varia Consortium; HUGO Pan-Asian SNP Consortium
Bibliographic Citation
Science, vol. 326, no. 5959, pp. 1541-1545
Publication Year
2009
Abstract
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
ISSN
0036-8075
Publisher
Amer Assoc Advancement Science
DOI
http://dx.doi.org/10.1126/science.1177074
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
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