Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity

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Title
Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity
Author(s)
S K Basha; K Govindaraju; R Manikandan; Jong Seog Ahn; Eun Young Bae; G Singaravelu
Bibliographic Citation
Colloids and Surfaces B-Biointerfaces, vol. 75, no. 2, pp. 405-409
Publication Year
2010
Abstract
Current discovery demonstrates the rapid formation of gold nanoparticles with guavanoic acid a phytochemical of Psidium guajava (Pg). The pharmacological capabilities of the phytochemicals present in the leaves of Pg and their ability to generate gold nanoparticles is presented herein. The new genre of green nanoparticles exhibit remarkable Protein Tyrosine Phosphatase 1B (PTP 1B) inhibitory activity and in vitro stability in various physiological medium including saline, histidine, cysteine, bovine serum albumin (BSA), human serum albumin (HSA) and buffers (pH 5, 7 and 9). It is predicted that this new technology will be felt greatly in several routes of pharmaceuticals.
Keyword
Biological synthesisGold nanoparticlesGuavanoic acidPTP 1B
ISSN
0927-7765
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.colsurfb.2009.09.008
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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