Changes in gene expression profile of medaka with acute toxicity of Arochlor 1260, a polychlorinated biphenyl mixture

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dc.contributor.authorS Yum-
dc.contributor.authorS Woo-
dc.contributor.authorY Kagami-
dc.contributor.authorHong-Seog Park-
dc.contributor.authorJ C Ryu-
dc.date.accessioned2017-04-19T09:16:47Z-
dc.date.available2017-04-19T09:16:47Z-
dc.date.issued2010-
dc.identifier.issn0742-8413-
dc.identifier.uri10.1016/j.cbpc.2009.08.007ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9311-
dc.description.abstractDifferential gene expression profiling was performed with a cDNA microarray in the liver tissue of the medaka fish, Oryzias latipes, after exposure to Arochlor 1260, a polychlorinated biphenyl (PCB) mixture, which is used as a coolant and insulating fluid for transformers and capacitors and is classified as a persistent organic pollutant. Twenty-six differentially expressed candidate genes were identified. The expression of 12 genes was up-regulated and that of 14 genes was down-regulated. These genes are associated with the cytoskeleton, development, endocrine/reproduction, immunity, metabolism, nucleic acid/protein binding, and signal transduction, or are uncategorized. The transcription of molecular biomarkers known to be involved in endocrine disruption (e.g., vitellogenins, choriogenins, and estrogen receptor α) was highly up-regulated. The same tendencies in gene expression changes were observed with real-time quantitative PCR (qRT-PCR) analysis, which was conducted to examine 12 selected candidate genes. These genes could be used as molecular biomarkers for biological responses to toxic chemicals, especially endocrine disrupting and carcinogenic chemical contamination in aquatic environments.-
dc.publisherElsevier-
dc.titleChanges in gene expression profile of medaka with acute toxicity of Arochlor 1260, a polychlorinated biphenyl mixture-
dc.title.alternativeChanges in gene expression profile of medaka with acute toxicity of Arochlor 1260, a polychlorinated biphenyl mixture-
dc.typeArticle-
dc.citation.titleComparative Biochemistry and Physiology C-Toxicology & Pharmacology-
dc.citation.number1-
dc.citation.endPage56-
dc.citation.startPage51-
dc.citation.volume151-
dc.contributor.affiliatedAuthorHong-Seog Park-
dc.contributor.alternativeName염승식-
dc.contributor.alternativeName우선옥-
dc.contributor.alternativeNameKagami-
dc.contributor.alternativeName박홍석-
dc.contributor.alternativeName류재천-
dc.identifier.bibliographicCitationComparative Biochemistry and Physiology C-Toxicology & Pharmacology, vol. 151, no. 1, pp. 51-56-
dc.identifier.doi10.1016/j.cbpc.2009.08.007-
dc.subject.keywordArochlor 1260-
dc.subject.keywordcDNA microarray-
dc.subject.keywordDifferential gene expression profile-
dc.subject.keywordOryzias latipes-
dc.subject.keywordPolychlorinated biphenyls (PCBs)-
dc.subject.keywordReal-time quantitative PCR-
dc.subject.localArochlor 1260-
dc.subject.localcDNA micro-array-
dc.subject.localcDNA microarray-
dc.subject.localDifferential gene expression profile-
dc.subject.localoryzias latipes-
dc.subject.localOryzias latipes-
dc.subject.localPolychlorinated biphenyls-
dc.subject.localPolychlorinated biphenyl-
dc.subject.localPolychlorinated biphenyls (PCBs)-
dc.subject.localReal-time quantitative PCR-
dc.subject.localreal-time quantitative polymerase chain reaction-
dc.subject.localreal-time quantitative PCR-
dc.description.journalClassY-
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