Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity

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dc.contributor.authorH W Seo-
dc.contributor.authorT M Hung-
dc.contributor.authorM Na-
dc.contributor.authorH J Jung-
dc.contributor.authorJ C Kim-
dc.contributor.authorJ S Choi-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorI Lee-
dc.contributor.authorK Bae-
dc.contributor.authorM Hattori-
dc.contributor.authorB S Min-
dc.date.accessioned2017-04-19T09:16:48Z-
dc.date.available2017-04-19T09:16:48Z-
dc.date.issued2009-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-009-2109-xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9313-
dc.description.abstractTo determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC 50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)- lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.-
dc.publisherPharmaceutical Soc Korea-
dc.titleSteroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity-
dc.title.alternativeSteroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage1579-
dc.citation.startPage1573-
dc.citation.volume32-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName서효원-
dc.contributor.alternativeNameHung-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName정현주-
dc.contributor.alternativeName김진철-
dc.contributor.alternativeName최재수-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName이익수-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeNameHattori-
dc.contributor.alternativeName민병선-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 32, no. 11, pp. 1573-1579-
dc.identifier.doi10.1007/s12272-009-2109-x-
dc.subject.keywordAnti-complementary activity-
dc.subject.keywordGanoderic acid Sz-
dc.subject.keywordGanoderma lucidum-
dc.subject.keywordLanostadiene triterpene-
dc.subject.keywordPolyporaceae-
dc.subject.localanticomplementary actvity-
dc.subject.localAnticomplementary activity-
dc.subject.localAnti-complementary activity-
dc.subject.localanti-complementary activity-
dc.subject.localanticomplementary activity-
dc.subject.localGanoderic acid Sz-
dc.subject.localGanoderma lucidum-
dc.subject.localganoderma lucidum-
dc.subject.localLanostadiene triterpene-
dc.subject.localPolyporaceae-
dc.subject.localpolyporaceae-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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