Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa

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Title
Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa
Author(s)
G H Xu; Young-hee Kim; Seung-Wook Chi; Soo-Jin Choo; In Ja RyooJong Seog Ahn; Ick Dong Yoo
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 2, pp. 513-515
Publication Year
2010
Abstract
Five iridoid glycosides were isolated from the MeOH extract of Hedyotis diffusa, and their structures were elucidated as E-6-O-p-methoxycinnamoyl scandoside methyl ester (1), Z-6-O-p-methoxycinnamoyl scandoside methyl ester (2), E-6-O-p-feruloyl scandoside methyl ester (3), E-6-O-p-coumaroyl scandoside methyl ester (4), and Z-6-O-p-coumaroyl scandoside methyl ester (5) by interpretation of their spectroscopic data. All the isolated compounds were evaluated for human neutrophil elastase inhibitory effect, and compound 1 showed potent activity with an IC50 value of 18.0 μM. The molecular docking simulation suggested a structural model for the inhibition of human neutrophil elastase by compound 1.
Keyword
Human neutrophil elastaseIridoid glycosidesHedyotis diffusa
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2009.11.109
Type
Article
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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