ChimerDB 2.0-a knowledgebase for fusion genes updated = ChimerDB 2.0-fusion genes 지식사이트 업데이트

Cited 69 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorP Kim-
dc.contributor.authorS Yoon-
dc.contributor.authorNamshin Kim-
dc.contributor.authorS Lee-
dc.contributor.authorM Ko-
dc.contributor.authorH Lee-
dc.contributor.authorH Kang-
dc.contributor.authorJ Kim-
dc.contributor.authorS Lee-
dc.date.accessioned2017-04-19T09:17:07Z-
dc.date.available2017-04-19T09:17:07Z-
dc.date.issued2010-
dc.identifier.issn0305-1048-
dc.identifier.uri10.1093/nar/gkp982ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9327-
dc.description.abstractChromosome translocations and gene fusions are frequent events in the human genome and have been found to cause diverse types of tumor. ChimerDB is a knowledgebase of fusion genes identified from bioinformatics analysis of transcript sequences in the GenBank and various other public resources such as the Sanger cancer genome project (CGP), OMIM, PubMed and the Mitelman's database. In this updated version, we significantly modified the algorithm of identifying fusion transcripts. Specifically, the new algorithm is more sensitive and has detected 2699 fusion transcripts with high confidence. Furthermore, it can identify interchromosomal translocations as well as the intrachromosomal deletions or inversions of large DNA segments. Importantly, results from the analysis of next-generation sequencing data in the short read archives are incorporated as well. We updated and integrated all contents (GenBank, Sanger CGP, OMIM, PubMed publications and the Mitelman's database), and the user-interface has been improved to support diverse types of searches and to enhance the user convenience especially in browsing PubMed articles. We also developed a new alignment viewer that should facilitate examining reliability of fusion transcripts and inferring functional significance. We expect ChimerDB 2.0, available at http://ercsb.ewha.ac.kr/fusiongene, to be a valuable tool in identifying biomarkers and drug targets.-
dc.publisherOxford Univ Press-
dc.titleChimerDB 2.0-a knowledgebase for fusion genes updated = ChimerDB 2.0-fusion genes 지식사이트 업데이트-
dc.title.alternativeChimerDB 2.0-a knowledgebase for fusion genes updated-
dc.typeArticle-
dc.citation.titleNucleic Acids Research-
dc.citation.numberD-
dc.citation.endPageD85-
dc.citation.startPageD81-
dc.citation.volume38-
dc.contributor.affiliatedAuthorNamshin Kim-
dc.contributor.alternativeName김보라-
dc.contributor.alternativeName윤서현-
dc.contributor.alternativeName김남신-
dc.contributor.alternativeName이상현-
dc.contributor.alternativeName고민정-
dc.contributor.alternativeName이혜승-
dc.contributor.alternativeName강현정-
dc.contributor.alternativeName김재상-
dc.contributor.alternativeName이상혁-
dc.identifier.bibliographicCitationNucleic Acids Research, vol. 38, no. D, pp. D81-D85-
dc.identifier.doi10.1093/nar/gkp982-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.