Tristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia

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dc.contributor.authorTae-Woo Kim-
dc.contributor.authorS Yim-
dc.contributor.authorByeong Jung Choe-
dc.contributor.authorYeo-Jin Jang-
dc.contributor.authorJ J Lee-
dc.contributor.authorBo Hwa Sohn-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorKyung Chan Park-
dc.date.accessioned2017-04-19T09:17:12Z-
dc.date.available2017-04-19T09:17:12Z-
dc.date.issued2010-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2009.11.174ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9336-
dc.description.abstractHypoxia-inducible factor-1 (HIF-1) is a transcription factor involved in the cancer cell adaptation to hypoxia, a leading cause of tumor malignancy. Thus, control of HIF-1α expression may assist in treatment of cancer. The expression of HIF-1α is finely regulated via alterations in not only HIF-1α protein stability but also mRNA stability. However, the molecular mechanisms of regulation of HIF-1α mRNA stability have not yet been fully elucidated. Here, we show that tristetraprolin (TTP) protein, of which the mRNA expression level is downregulated in most of hepatocellular carcinoma tissues, bound directly to the 3′-UTR of HIF-1α mRNA containing eight putative TTP-binding motifs, AU-rich elements (AUUUA), to downregulate stability. Furthermore, TTP expression was induced in hypoxic cells, and overexpression of TTP repressed the hypoxic induction of HIF-1α protein. Taken together, these data suggest that TTP is a modulator of HIF-1α expression during hypoxia and may play a physiological role in regulation between cellular adaptation and apoptosis in prolonged hypoxia. In addition, cancer cells may benefit from the downregulation of TTP, which subsequently increases HIF-1α expression and assists with the adaptation of cancer cells to hypoxia.-
dc.publisherElsevier-
dc.titleTristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia-
dc.title.alternativeTristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage968-
dc.citation.startPage963-
dc.citation.volume391-
dc.contributor.affiliatedAuthorTae-Woo Kim-
dc.contributor.affiliatedAuthorByeong Jung Choe-
dc.contributor.affiliatedAuthorYeo-Jin Jang-
dc.contributor.affiliatedAuthorBo Hwa Sohn-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorKyung Chan Park-
dc.contributor.alternativeName김태우-
dc.contributor.alternativeName임수진-
dc.contributor.alternativeName최병중-
dc.contributor.alternativeName장예진-
dc.contributor.alternativeName이정주-
dc.contributor.alternativeName손보화-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName박경찬-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 963-968-
dc.identifier.doi10.1016/j.bbrc.2009.11.174-
dc.subject.keywordAU-rich element-
dc.subject.keywordHIF-1α-
dc.subject.keywordTristetraprolin-
dc.subject.keywordTTP-
dc.subject.keywordUTR-
dc.subject.localAU-rich element-
dc.subject.localHif1α-
dc.subject.localHIF-1α-
dc.subject.localHIF1α-
dc.subject.localTristetraprolin-
dc.subject.localtristetraprolin-
dc.subject.localTTP-
dc.subject.localUTR-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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