Suppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system

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dc.contributor.authorHye Sun Lim-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorH J Lee-
dc.contributor.authorYoung Won Chin-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorD E Sok-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:17:13Z-
dc.date.available2017-04-19T09:17:13Z-
dc.date.issued2009-
dc.identifier.issnI000-0171-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9342-
dc.description.abstractBioactivity-guided fractionation of Anthricus sylvestris extract, using matrix metalloproteinase-9 (MMP-9) assay, led to the isolation of deoxypodophyllotoxin (1), falcarindiol (2), (-)-hinokinin (3), and (-)-hibalactone (4). All compounds obtained were evaluated for the inhibitory activities against MMP-9 in luciferase and zymographic assays. Of these compounds, compounds 1 (IC50 0.5 nM) and 2 (IC50 8.4 μM) were found to inhibit MMP-9 expression in the PGL4.14-MMP-9-Luc plasmid transfected Raw 264.7 cells, and MMP-9 production in a gelatin zymographic assay.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleSuppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system-
dc.title.alternativeSuppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system-
dc.typeArticle-
dc.citation.titleJournal of Korean Society for Applied Biological Chemistry-
dc.citation.number6-
dc.citation.endPage625-
dc.citation.startPage620-
dc.citation.volume52-
dc.contributor.affiliatedAuthorHye Sun Lim-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorYoung Won Chin-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName임혜선-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이호재-
dc.contributor.alternativeName진영원-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName석대은-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationJournal of Korean Society for Applied Biological Chemistry, vol. 52, no. 6, pp. 620-625-
dc.subject.keywordAnthriscus sylvestris-
dc.subject.keyworddeoxypodophyllotoxin-
dc.subject.keywordfalcarindiol-
dc.subject.keywordluciferase assay, matrix-
dc.subject.keywordmetalloproteinase-9-
dc.subject.keywordzymography-
dc.subject.localanthriscus sylvestris-
dc.subject.localAnthriscus sylvestris-
dc.subject.localdeoxypodophyllotoxin-
dc.subject.localfalcarindiol-
dc.subject.localluciferase assay, matrix-
dc.subject.localmetalloproteinase-9 (MMP-9)-
dc.subject.localmetalloproteinase-9-
dc.subject.localZymography-
dc.subject.localzymography-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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