Suppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hye Sun Lim | - |
| dc.contributor.author | Sei Ryang Oh | - |
| dc.contributor.author | H J Lee | - |
| dc.contributor.author | Young Won Chin | - |
| dc.contributor.author | Kyung Seop Ahn | - |
| dc.contributor.author | D E Sok | - |
| dc.contributor.author | Hyeong Kyu Lee | - |
| dc.date.accessioned | 2017-04-19T09:17:13Z | - |
| dc.date.available | 2017-04-19T09:17:13Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.issn | I000-0171 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9342 | - |
| dc.description.abstract | Bioactivity-guided fractionation of Anthricus sylvestris extract, using matrix metalloproteinase-9 (MMP-9) assay, led to the isolation of deoxypodophyllotoxin (1), falcarindiol (2), (-)-hinokinin (3), and (-)-hibalactone (4). All compounds obtained were evaluated for the inhibitory activities against MMP-9 in luciferase and zymographic assays. Of these compounds, compounds 1 (IC50 0.5 nM) and 2 (IC50 8.4 μM) were found to inhibit MMP-9 expression in the PGL4.14-MMP-9-Luc plasmid transfected Raw 264.7 cells, and MMP-9 production in a gelatin zymographic assay. | - |
| dc.publisher | Korea Soc-Assoc-Inst | - |
| dc.title | Suppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system | - |
| dc.title.alternative | Suppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected Raw 264.7 cell based assay system | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Korean Society for Applied Biological Chemistry | - |
| dc.citation.number | 6 | - |
| dc.citation.endPage | 625 | - |
| dc.citation.startPage | 620 | - |
| dc.citation.volume | 52 | - |
| dc.contributor.affiliatedAuthor | Hye Sun Lim | - |
| dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
| dc.contributor.affiliatedAuthor | Young Won Chin | - |
| dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
| dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
| dc.contributor.alternativeName | 임혜선 | - |
| dc.contributor.alternativeName | 오세량 | - |
| dc.contributor.alternativeName | 이호재 | - |
| dc.contributor.alternativeName | 진영원 | - |
| dc.contributor.alternativeName | 안경섭 | - |
| dc.contributor.alternativeName | 석대은 | - |
| dc.contributor.alternativeName | 이형규 | - |
| dc.identifier.bibliographicCitation | Journal of Korean Society for Applied Biological Chemistry, vol. 52, no. 6, pp. 620-625 | - |
| dc.subject.keyword | Anthriscus sylvestris | - |
| dc.subject.keyword | deoxypodophyllotoxin | - |
| dc.subject.keyword | falcarindiol | - |
| dc.subject.keyword | luciferase assay, matrix | - |
| dc.subject.keyword | metalloproteinase-9 | - |
| dc.subject.keyword | zymography | - |
| dc.subject.local | anthriscus sylvestris | - |
| dc.subject.local | Anthriscus sylvestris | - |
| dc.subject.local | deoxypodophyllotoxin | - |
| dc.subject.local | falcarindiol | - |
| dc.subject.local | luciferase assay, matrix | - |
| dc.subject.local | metalloproteinase-9 (MMP-9) | - |
| dc.subject.local | metalloproteinase-9 | - |
| dc.subject.local | Zymography | - |
| dc.subject.local | zymography | - |
| dc.description.journalClass | N | - |
- Appears in Collections:
- Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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