Increase of RhoB in γ-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells

Cited 19 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorC H Kim-
dc.contributor.authorMi Sun Won-
dc.contributor.authorJ H Choi-
dc.contributor.authorJi Won Ahn-
dc.contributor.authorBo Kyung Kim-
dc.contributor.authorK B Song-
dc.contributor.authorC M Kang-
dc.contributor.authorKyung Sook Chung-
dc.date.accessioned2017-04-19T09:17:14Z-
dc.date.available2017-04-19T09:17:14Z-
dc.date.issued2010-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2009.12.012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9354-
dc.description.abstractThe Ras-related small GTP-binding protein RhoB is known to be a pro-apoptotic protein and immediate-early inducible by genotoxic stresses. In addition, JNK activation is known to function in γ-radiation-induced apoptosis. However, it is unclear how JNK activation and γ-radiation-dependent RhoB induction are related. Here we verified the relationship between JNK activation and RhoB induction. RhoB induction by γ-radiation occurred at the transcriptional level and transcriptional activation of RhoB was concomitant with an increase in RhoB protein. γ-Radiation-induced RhoB expression was markedly attenuated by pretreatment with a JNK-specific inhibitor, SP600125, but not by a p38 MAPK inhibitor, SB203580. Inhibition of JNK caused a decrease in early apoptotic cell death that correlated with RhoB expression. However, PI3K inhibition had no significant effects, indicating that the AKT survival pathway was not involved. The siRNA knockdown of JNK resulted in a decrease in RhoB expression and the siRNA knockdown of RhoB restored cell growth even in the γ-irradiated cells. These results suggest that RhoB regulation involves the JNK pathway and contributes to the early apoptotic response of Jurkat T cells to γ-radiation.-
dc.publisherElsevier-
dc.titleIncrease of RhoB in γ-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells-
dc.title.alternativeIncrease of RhoB in γ-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage1186-
dc.citation.startPage1182-
dc.citation.volume391-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.affiliatedAuthorJi Won Ahn-
dc.contributor.affiliatedAuthorBo Kyung Kim-
dc.contributor.affiliatedAuthorKyung Sook Chung-
dc.contributor.alternativeName김천호-
dc.contributor.alternativeName원미선-
dc.contributor.alternativeName최정해-
dc.contributor.alternativeName안지원-
dc.contributor.alternativeName김보경-
dc.contributor.alternativeName송경빈-
dc.contributor.alternativeName강창모-
dc.contributor.alternativeName정경숙-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 391, no. 2, pp. 1182-1186-
dc.identifier.doi10.1016/j.bbrc.2009.12.012-
dc.subject.keywordγ-Radiation-
dc.subject.keywordApoptosis-
dc.subject.keywordJNK-
dc.subject.keywordJurkat-
dc.subject.keywordRhoB-
dc.subject.localγ-Radiation-
dc.subject.localγ-radiation-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localJNK-
dc.subject.localJurkat-
dc.subject.localRhoB-
dc.subject.localRhob-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.