Heterologous microarray hybridization used for differential gene expression profiling in Benzo[a]pyrene-exposed marine medaka

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dc.contributor.authorS Woo-
dc.contributor.authorH Won-
dc.contributor.authorH Y Jeon-
dc.contributor.authorB Kim-
dc.contributor.authorT K Lee-
dc.contributor.authorHong-Seog Park-
dc.contributor.authorS Yum-
dc.date.accessioned2017-04-19T09:17:16Z-
dc.date.available2017-04-19T09:17:16Z-
dc.date.issued2009-
dc.identifier.issnI000-0184-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9361-
dc.description.abstractDifferential gene expression profiling was performed in the hepatic tissue of marine medaka fish (Oryzias javanicus) after exposure to benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), by heterologous hybridization using a medaka cDNA microarray. Thirty-eight differentially expressed candidate genes, of which 23 were induced and 15 repressed (P?0.01), were identified and found to be associated with cell cycle, development, endocrine/reproduction, immune, metabolism, nucleic acid/protein binding, signal transduction, or non-categorized. The presumptive physiological changes induced by BaP exposure were identified after considering the biological function of each gene candidate. The results obtained in this study will allow future studies to assess the molecular mechanisms of BaP toxicity and the development of a systems biology approach to the stress biology of organic chemicals.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleHeterologous microarray hybridization used for differential gene expression profiling in Benzo[a]pyrene-exposed marine medaka-
dc.title.alternativeHeterologous microarray hybridization used for differential gene expression profiling in Benzo[a]pyrene-exposed marine medaka-
dc.typeArticle-
dc.citation.titleMolecular & Cellular Toxicology-
dc.citation.number4-
dc.citation.endPage290-
dc.citation.startPage283-
dc.citation.volume5-
dc.contributor.affiliatedAuthorHong-Seog Park-
dc.contributor.alternativeName우선옥-
dc.contributor.alternativeName원효경-
dc.contributor.alternativeName전해영-
dc.contributor.alternativeName김보라-
dc.contributor.alternativeName이택균-
dc.contributor.alternativeName박홍석-
dc.contributor.alternativeName염승식-
dc.identifier.bibliographicCitationMolecular & Cellular Toxicology, vol. 5, no. 4, pp. 283-290-
dc.subject.keywordMarine medaka-
dc.subject.keywordOryzias javanicus-
dc.subject.keywordHeterologous hybridization-
dc.subject.keywordMicroarray benzo[a]pyrene (BaP)-
dc.subject.keywordDifferential gene expression profile-
dc.subject.localMarine medaka-
dc.subject.localOryzias javanicus-
dc.subject.localoryzias javanicus-
dc.subject.localHeterologous hybridization-
dc.subject.localMicroarray benzo[a]pyrene (BaP)-
dc.subject.localDifferential gene expression profile-
dc.description.journalClassY-
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