Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes

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dc.contributor.authorS H Lee-
dc.contributor.authorK Y Kim-
dc.contributor.authorS Y Ryu-
dc.contributor.authorY Yoon-
dc.contributor.authorD H Hahm-
dc.contributor.authorS A Kang-
dc.contributor.authorS H Cho-
dc.contributor.authorJ S Lim-
dc.contributor.authorE Y Moon-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorD Y Yoon-
dc.contributor.authorY Yang-
dc.date.accessioned2017-04-19T09:17:16Z-
dc.date.available2017-04-19T09:17:16Z-
dc.date.issued2010-
dc.identifier.issn01455680-
dc.identifier.uri10.1170/138ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9363-
dc.description.abstractAsarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-α and peroxisome proliferator activated receptor-γ, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPARγ and C/EBPα and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.-
dc.publisherC M B Assoc-
dc.titleAsarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes-
dc.title.alternativeAsarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes-
dc.typeArticle-
dc.citation.titleCellular and Molecular Biology-
dc.citation.number3-
dc.citation.endPage1222-
dc.citation.startPage1215-
dc.citation.volume56-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName이수희-
dc.contributor.alternativeName김근용-
dc.contributor.alternativeName류시용-
dc.contributor.alternativeName윤유식-
dc.contributor.alternativeName함대현-
dc.contributor.alternativeName강순아-
dc.contributor.alternativeName조수현-
dc.contributor.alternativeName임종석-
dc.contributor.alternativeName문은이-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName양영-
dc.identifier.bibliographicCitationCellular and Molecular Biology, vol. 56, no. 3, pp. 1215-1222-
dc.identifier.doi10.1170/138-
dc.subject.keywordC/EBPα-
dc.subject.keywordPPARγ-
dc.subject.keywordAdiponectin-
dc.subject.keywordAsarone-
dc.subject.keywordHormone-sensitive lipase-
dc.subject.localC/EBPα-
dc.subject.localPPARγ-
dc.subject.localPPAR-γ-
dc.subject.localAdiponectin-
dc.subject.localAsarone-
dc.subject.localHormone-sensitive lipase-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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