Inhibition of neuraminidase activity by polyphenol compounds isoalated from the roots of Glycyrrhiza uralensis = 감초뿌리로부터 뉴라미니데이즈 저해제인 폴리페놀 화합물 개발

Cited 86 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorJang Hun Kim-
dc.contributor.authorSu-Jin Park-
dc.contributor.authorJong Sun Chang-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorK H Bae-
dc.contributor.authorK H Park-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:17:16Z-
dc.date.available2017-04-19T09:17:16Z-
dc.date.issued2010-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2009.12.106ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9364-
dc.description.abstractWe isolated 18 polyphenols with neuraminidase inhibitory activity from methanol extracts of the roots of Glycyrrhiza uralensis. These polyphenols consisted of four chalcones (1-4), nine flavonoids (5-13), four coumarins (14-17), and one phenylbenzofuran (18). When we tested the effects of these individual compounds and analogs thereof on neuraminidase activation, we found that isoliquiritigenin (1, IC50 = 9.0 μM) and glycyrol (14, IC50 = 3.1 μM) had strong inhibitory activity. Structure-activity analysis showed that the furan rings of the polyphenols were essential for neuraminidase inhibitory activity, and that this activity was enhanced by the apioside group on the chalcone and flavanone backbone. In addition, the presence of a five-membered ring between C-4 and C-2′ in coumestan was critical for neuraminidase inhibition. All neuraminidase inhibitors screened were found to be reversible noncompetitive inhibitors.-
dc.publisherElsevier-
dc.titleInhibition of neuraminidase activity by polyphenol compounds isoalated from the roots of Glycyrrhiza uralensis = 감초뿌리로부터 뉴라미니데이즈 저해제인 폴리페놀 화합물 개발-
dc.title.alternativeInhibition of neuraminidase activity by polyphenol compounds isoalated from the roots of Glycyrrhiza uralensis-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number3-
dc.citation.endPage974-
dc.citation.startPage971-
dc.citation.volume20-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorJang Hun Kim-
dc.contributor.affiliatedAuthorSu-Jin Park-
dc.contributor.affiliatedAuthorJong Sun Chang-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName김장훈-
dc.contributor.alternativeName박수진-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName박기훈-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 20, no. 3, pp. 971-974-
dc.identifier.doi10.1016/j.bmcl.2009.12.106-
dc.subject.keywordAnti-influenza-
dc.subject.keywordCoumestan-
dc.subject.keywordGlycyrrhiza uralensis-
dc.subject.keywordNeuraminidase-
dc.subject.localAnti-influenza-
dc.subject.localCoumestan-
dc.subject.localCoumestans-
dc.subject.localGlycyrrhiza uralensis-
dc.subject.localneuraminidase-
dc.subject.localNeuraminidase-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.