ACAT (Acyl-CoA:cholesterol Acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas nakai = 참당귀(Angelica gigas)에서 분리한 pyranocurmarin 성분의 ACAT 저해활성 및 부위별 pyranocurmarin 성분의 함량 분석

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dc.contributor.authorG S Kim-
dc.contributor.authorC G Park-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorS W Cha-
dc.contributor.authorN I Baek-
dc.contributor.authorK S Song-
dc.date.accessioned2017-04-19T09:17:16Z-
dc.date.available2017-04-19T09:17:16Z-
dc.date.issued2009-
dc.identifier.issn12292737-
dc.identifier.uri10.3839/jabc.2009.032ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9365-
dc.description.abstractTwo pyranocoumarin constituents have been isolated from Angelica gigas and were identified as decursinol angelate (1) and decursin (2) by means of NMR analysis, respectively. Human acyl-CoA: cholesterol acyltransferase (hACAT) inhibitory activity of decursinol angelate (1) and decursin (2) was evaluated. Decursin (2) showed significantly inhibitory activity against hACAT1 and hACAT2 with IC50 value of 137 and 168 μM, respectively, whereas decursinol angelate (1) exhibited weak ACAT inhibitory activity. These results suggested that decusin from A. gigas might be effective for the prevention and the treatment of hypercholesterolemia or atherosclerosis by inhibitory effect on hACAT. The contents of decursinol angelate (1) and decursin (2) were analyzed in various parts of A. gigas including flower, seed, leaf and root using LC/MS/MS (ESI, positive ion mode, MRM mode). The content of decursinol angelate was increased in order of flower, seed, leaf, and root and decursin content was increased in order of flower, seed, leaf, and root. It was expected that unused parts including leaf and flower of A. gigas might be useful as new functional sources by their high contents of decursin and decursinol angelate.-
dc.publisherSpringer-
dc.titleACAT (Acyl-CoA:cholesterol Acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas nakai = 참당귀(Angelica gigas)에서 분리한 pyranocurmarin 성분의 ACAT 저해활성 및 부위별 pyranocurmarin 성분의 함량 분석-
dc.title.alternativeACAT (Acyl-CoA:cholesterol Acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas nakai-
dc.typeArticle-
dc.citation.titleJournal of Applied Biological Chemistry-
dc.citation.number4-
dc.citation.endPage194-
dc.citation.startPage187-
dc.citation.volume52-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName김금숙-
dc.contributor.alternativeName박춘근-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName차선우-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName송경식-
dc.identifier.bibliographicCitationJournal of Applied Biological Chemistry, vol. 52, no. 4, pp. 187-194-
dc.identifier.doi10.3839/jabc.2009.032-
dc.subject.keywordACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.keywordAngelica gigas-
dc.subject.keyworddecursin-
dc.subject.keyworddecursinol angelate-
dc.subject.keywordLC/MS/MS-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAngelica gigas-
dc.subject.localdecursin-
dc.subject.localDecursin-
dc.subject.localdecursinol angelate-
dc.subject.localDecursinol angelate-
dc.subject.localLC/MS/MS-
dc.subject.localLC-MS/MS-
dc.description.journalClassY-
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Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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