Inhibitory effect of acetylshikonin from roots of Lithospermum erythrorhizon on LDL oxidation and FPTase activity = 지치뿌리로부터 분리한 acetylshikonin의 LDL 산화 저해활성과 FPTase 저해활성

Cited 1 time in scopus
Metadata Downloads
Title
Inhibitory effect of acetylshikonin from roots of Lithospermum erythrorhizon on LDL oxidation and FPTase activity = 지치뿌리로부터 분리한 acetylshikonin의 LDL 산화 저해활성과 FPTase 저해활성
Author(s)
G S Kim; Tae Sook Jeong; Byoung-Mog Kwon; Y O Kim; S W Cha; K S Song; N I Baek
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 52, no. 4, pp. 221-225
Publication Year
2009
Abstract
Lithospermum erythrorhizon has been known well as one of traditional medicine for fever reduction, detoxication, and blood circulation improvement. This study was carried out to isolate biological active compounds from roots of Lithospermum erythrorhizon and to investigate their low density lipoprotein (LDL) antioxidant and anticancer activities. The hexane extract of Lithospermi Radix has been separated on silica gel chromatography and a naphthoquinone pigment compound 1 has been isolated. The structure of the compound 1 has been identified by spectroscopic technique, including MS and NMR, as acetylshikonin (1). Acetylshikonin showed significantly inhibitory activity on -induced human LDL oxidation with value of and obvious anticancer effect by inhibiting farnesyl:protein transferase (FPTase) activity with value of , which suggested that acetylshikonin might be useful for the treatment of atherosclerosis and cancer.
Keyword
acetylshikoninFPTaseLDL oxidationLithospermum erythrorhizon
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2009.038
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.