Neuroprotective effects of Triticum aestivum L. against β-Amyloid-induced cell death and memory impairments

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Title
Neuroprotective effects of Triticum aestivum L. against β-Amyloid-induced cell death and memory impairments
Author(s)
J H Jang; C Y Kim; S H Lim; C H Yang; K S Song; H S Han; Hyeong Kyu Lee; J Lee
Bibliographic Citation
Phytotherapy Research, vol. 24, no. 1, pp. 76-84
Publication Year
2010
Abstract
β-Amyloid (Aβ) is a key component of senile plaques, neuropathological hallmarks of Alzheimer's disease (AD) and has been reported to induce cell death via oxidative stress. This study investigated the protective effects of Triticum aestivum L. (TAL) on Aβ-induced apoptosis in SH-SY5Y cells and cognitive dysfunctions in Sprague-Dawley (SD) rats. Cells treated with Aβ exhibited decreased viability and apoptotic features, such as DNA fragmentation, alterations in mitochondria and an increased Bax/Bcl-2 ratio, which were attenuated by TAL extract (TALE) pretreatment. To elucidate the neuroprotective mechanisms of TALE, the study examined Aβ-induced oxidative stress and cellular defense. TALE pretreatment suppressed Aβ-increased intracellular accumulation of reactive oxygen species (ROS) via up-regulation of glutathione, an essential endogenous antioxidant. To further verify the effect of TALE on memory impairments, Aβ or scopolamine was injected in SD rats and a water maze task conducted as a spatial memory test. Aβ or scopolamine treatment increased the time taken to find the platform during training trials, which was decreased by TALE pretreatment. Furthermore, one of the active components of TALE, total dietary fiber also effectively inhibited Aβ-induced cytotoxicity and scopolamine-caused memory deficits. These results suggest that TALE may have preventive and/or therapeutic potential in the management of AD.
Keyword
β-amyloidApoptosisMemoryOxidative stressScopolamineTriticum aestivum L.
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.2871
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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