PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica

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dc.contributor.authorC Seo-
dc.contributor.authorY H Choi-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorJ H Yim-
dc.contributor.authorH K Lee-
dc.contributor.authorH Oh-
dc.date.accessioned2017-04-19T09:17:20Z-
dc.date.available2017-04-19T09:17:20Z-
dc.date.issued2009-
dc.identifier.issn1475-6366-
dc.identifier.uri10.1080/14756360802667811ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9388-
dc.description.abstractThe selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried sample of the Antarctic lichen Umbilicaria antarctica was found to exhibit significant inhibitory effect, and the bioassay-guided fractionation and purification afforded three related lichen metabolites 1-3. Compounds 1-3 were identified as gyrophoric acid (1), lecanoric acid (2), and methyl orsellinate (3) mainly by analysis of NMR and MS data. These compounds inhibited PTP1B activity with 50% inhibitory concentration values of 3.6 ± 0.04 μM, 31 ± 2.7 μM, and 277 ± 8.6 μM, respectively. Furthermore, the kinetic analysis of PTP1B inhibition by compound 1 suggested that the compound inhibited PTP1B activity in a non-competitive manner.-
dc.publisherT&F (Taylor & Francis)-
dc.titlePTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica-
dc.title.alternativePTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica-
dc.typeArticle-
dc.citation.titleJournal of Enzyme Inhibition and Medicinal Chemistry-
dc.citation.number5-
dc.citation.endPage1137-
dc.citation.startPage1133-
dc.citation.volume24-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName서찬건-
dc.contributor.alternativeName최윤혁-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName임정한-
dc.contributor.alternativeName이홍금-
dc.contributor.alternativeName오현철-
dc.identifier.bibliographicCitationJournal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 5, pp. 1133-1137-
dc.identifier.doi10.1080/14756360802667811-
dc.subject.keywordAntarctic lichen-
dc.subject.keywordLichen metabolites-
dc.subject.keywordNon-competitive inhibitor-
dc.subject.keywordProtein tyrosine phosphatase 1B (PTP1B)-
dc.subject.keywordUmbilicaria antarctica-
dc.subject.localAntarctic lichen-
dc.subject.localLichen metabolites-
dc.subject.locallichen metabolites-
dc.subject.localNon-competitive inhibitor-
dc.subject.localnon-competitive inhibitors-
dc.subject.localNon-competitive inhibitors-
dc.subject.localnon-competitive inhibitor-
dc.subject.localprotein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase-1B (PTP1B)-
dc.subject.localProtein tyrosine phosphatase 1B-
dc.subject.localprotein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localprotein tyrosine phosphatase 1B (FTPIB)-
dc.subject.localProtein tyrosine phosphatase 1B (PTP1B)-
dc.subject.localUmbilicaria antarctica-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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