Effects of V279F in the Lp-PLA2 gene on markers of oxidative stress and inflammation in Koreans

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dc.contributor.authorJ K Paik-
dc.contributor.authorJ S Chae-
dc.contributor.authorY Jang-
dc.contributor.authorJ Y Kim-
dc.contributor.authorO Y Kim-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorS H Lee-
dc.contributor.authorJ H Lee-
dc.date.accessioned2017-04-19T09:17:22Z-
dc.date.available2017-04-19T09:17:22Z-
dc.date.issued2010-
dc.identifier.issn0009-8981-
dc.identifier.uri10.1016/j.cca.2009.12.021ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9405-
dc.description.abstractBackground: A single nucleotide polymorphism (SNP), V279F, in the lipoprotein-associated phospholipase A2 (Lp-PLA2) gene is known to influence enzyme activity. It is unclear whether Lp-PLA2 exerts pro- or antiatherogenic effects in humans. We investigated the interplay between V279F, Lp-PLA2 activity, oxidative stress and inflammation. Methods: We genotyped 2914 healthy Koreans (43-79years) for the Lp-PLA2 V279F and measured anthropometric parameters, lipid profile, fatty acid composition, lipid peroxides, inflammatory markers and Lp-PLA2 levels. Results: Lp-PLA2 activity was 24% lower in V/F subjects (n=641) than in those with the V/V genotype (n=2227). Enzyme activity was undetectable in F/F subjects. Lp-PLA2 activity was positively correlated with LDL-cholesterol (r=0.134, P<0.001), ox-LDL (r=0.064, P<0.01), 8-epi-PGF2α (r=0.198, P<0.001), free fatty acid (r=0.082, P<0.001), and fibrinogen (r=0.112, P<0.01) levels. Additionally, ox-LDL, 8-epi-PGF2α, free fatty acid, and fibrinogen levels were positively correlated with hs-CRP. V279F was associated with LDL-cholesterol and arachidonic acid (AA) in serum phospholipid. F/F subjects had lower LDL-cholesterol than V/V subjects (V/V: 120.9±0.69, V/F: 119.4±1.26, F/F: 109.2±4.84mg/dl, P=0.025). A significant association between the F/F genotype and increasing AA in serum phospholipids was found in subjects with high LDL-cholesterol (≥130mg/dl) (P=0.003) but not in those with low LDL-cholesterol (<130mg/dl). F/F subjects in the high LDL-cholesterol group had CRP concentrations about three times higher than those with V/V or V/F genotypes (V/V: 1.25±0.09, V/F: 0.97±0.12, F/F: 3.20±0.88mg/dl, P<0.001). Conclusions: The recessive effects of Lp-PLA2 V279F on LDL-cholesterol and significant correlations between Lp-PLA2 activity and LDL-cholesterol, 8-epi-PGF2α and fibrinogen support a pro-oxidative or pro-atherogenic role for this enzyme. Paradoxically, the combination of the complete deficiency of Lp-PLA2 activity and high LDL-cholesterol enhanced lipid peroxidation and inflammation.-
dc.publisherElsevier-
dc.titleEffects of V279F in the Lp-PLA2 gene on markers of oxidative stress and inflammation in Koreans-
dc.title.alternativeEffects of V279F in the Lp-PLA2 gene on markers of oxidative stress and inflammation in Koreans-
dc.typeArticle-
dc.citation.titleClinica Chimica Acta-
dc.citation.number7-
dc.citation.endPage493-
dc.citation.startPage486-
dc.citation.volume411-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName백진경-
dc.contributor.alternativeName채제숙-
dc.contributor.alternativeName장양수-
dc.contributor.alternativeName김지영-
dc.contributor.alternativeName김오연-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이상현-
dc.contributor.alternativeName이종호-
dc.identifier.bibliographicCitationClinica Chimica Acta, vol. 411, no. 7, pp. 486-493-
dc.identifier.doi10.1016/j.cca.2009.12.021-
dc.subject.keywordInflammation-
dc.subject.keywordLDL-cholesterol-
dc.subject.keywordLp-PLA2-
dc.subject.keywordOxidative stress-
dc.subject.keywordV279F-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localnflammation-
dc.subject.localLDL-cholesterol-
dc.subject.localLp-PLA2-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localoxidative stress-
dc.subject.localV279F-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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