DC Field | Value | Language |
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dc.contributor.author | J K Paik | - |
dc.contributor.author | J S Chae | - |
dc.contributor.author | Y Jang | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | O Y Kim | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | S H Lee | - |
dc.contributor.author | J H Lee | - |
dc.date.accessioned | 2017-04-19T09:17:22Z | - |
dc.date.available | 2017-04-19T09:17:22Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | 10.1016/j.cca.2009.12.021 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9405 | - |
dc.description.abstract | Background: A single nucleotide polymorphism (SNP), V279F, in the lipoprotein-associated phospholipase A2 (Lp-PLA2) gene is known to influence enzyme activity. It is unclear whether Lp-PLA2 exerts pro- or antiatherogenic effects in humans. We investigated the interplay between V279F, Lp-PLA2 activity, oxidative stress and inflammation. Methods: We genotyped 2914 healthy Koreans (43-79years) for the Lp-PLA2 V279F and measured anthropometric parameters, lipid profile, fatty acid composition, lipid peroxides, inflammatory markers and Lp-PLA2 levels. Results: Lp-PLA2 activity was 24% lower in V/F subjects (n=641) than in those with the V/V genotype (n=2227). Enzyme activity was undetectable in F/F subjects. Lp-PLA2 activity was positively correlated with LDL-cholesterol (r=0.134, P<0.001), ox-LDL (r=0.064, P<0.01), 8-epi-PGF2α (r=0.198, P<0.001), free fatty acid (r=0.082, P<0.001), and fibrinogen (r=0.112, P<0.01) levels. Additionally, ox-LDL, 8-epi-PGF2α, free fatty acid, and fibrinogen levels were positively correlated with hs-CRP. V279F was associated with LDL-cholesterol and arachidonic acid (AA) in serum phospholipid. F/F subjects had lower LDL-cholesterol than V/V subjects (V/V: 120.9±0.69, V/F: 119.4±1.26, F/F: 109.2±4.84mg/dl, P=0.025). A significant association between the F/F genotype and increasing AA in serum phospholipids was found in subjects with high LDL-cholesterol (≥130mg/dl) (P=0.003) but not in those with low LDL-cholesterol (<130mg/dl). F/F subjects in the high LDL-cholesterol group had CRP concentrations about three times higher than those with V/V or V/F genotypes (V/V: 1.25±0.09, V/F: 0.97±0.12, F/F: 3.20±0.88mg/dl, P<0.001). Conclusions: The recessive effects of Lp-PLA2 V279F on LDL-cholesterol and significant correlations between Lp-PLA2 activity and LDL-cholesterol, 8-epi-PGF2α and fibrinogen support a pro-oxidative or pro-atherogenic role for this enzyme. Paradoxically, the combination of the complete deficiency of Lp-PLA2 activity and high LDL-cholesterol enhanced lipid peroxidation and inflammation. | - |
dc.publisher | Elsevier | - |
dc.title | Effects of V279F in the Lp-PLA2 gene on markers of oxidative stress and inflammation in Koreans | - |
dc.title.alternative | Effects of V279F in the Lp-PLA2 gene on markers of oxidative stress and inflammation in Koreans | - |
dc.type | Article | - |
dc.citation.title | Clinica Chimica Acta | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 493 | - |
dc.citation.startPage | 486 | - |
dc.citation.volume | 411 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 백진경 | - |
dc.contributor.alternativeName | 채제숙 | - |
dc.contributor.alternativeName | 장양수 | - |
dc.contributor.alternativeName | 김지영 | - |
dc.contributor.alternativeName | 김오연 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 이상현 | - |
dc.contributor.alternativeName | 이종호 | - |
dc.identifier.bibliographicCitation | Clinica Chimica Acta, vol. 411, no. 7, pp. 486-493 | - |
dc.identifier.doi | 10.1016/j.cca.2009.12.021 | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | LDL-cholesterol | - |
dc.subject.keyword | Lp-PLA2 | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | V279F | - |
dc.subject.local | Inflammation | - |
dc.subject.local | inflammation | - |
dc.subject.local | nflammation | - |
dc.subject.local | LDL-cholesterol | - |
dc.subject.local | Lp-PLA2 | - |
dc.subject.local | OXIDATIVE STRESS | - |
dc.subject.local | Oxidative Stress | - |
dc.subject.local | Oxidative stre | - |
dc.subject.local | Oxidative stress | - |
dc.subject.local | oxidative stress | - |
dc.subject.local | V279F | - |
dc.description.journalClass | Y | - |
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