Antiviral and anticancer activities of 13(E)-labd-13-ene-8α,15-diol isolated from Brachyglottis monroi

Cited 5 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHwa-Jung Choi-
dc.contributor.authorJ H Song-
dc.contributor.authorDur Han Kwon-
dc.contributor.authorS H Baek-
dc.date.accessioned2017-04-19T09:17:23Z-
dc.date.available2017-04-19T09:17:23Z-
dc.date.issued2010-
dc.identifier.issn0951418X-
dc.identifier.uri10.1002/ptr.2875ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9410-
dc.description.abstractThe antiviral activity of 13(E)-labd-13-ene-8α,15-diol (1), isolated from Brachyglottis monroi, was examined against human rhinovirus 2 (HRV2) and 3 (HRV3), and the anticancer activity on human cancer cells (A549 and Hep2). Compound (1) showed strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 μg/mL, respectively, and a 50% cytotoxicity concentration (CC50) of 59.45 μg/mL. Ribavirin only showed anti-HRV3 activity with an IC50 of 30.48 mg/mL and a CC50 > 100 μg/mL. The addition of compound (1) to HRV-infected HeLa cells directly reduced the formation of visible cytopathic effect (CPE) and it directly interacted with HRV particles. Furthermore, A549 and Hep2 cells incubated with 32 μg/mL of compound (1) for 48 h exhibited antilung and antilaryngeal cancer activities, with a viability of less than 50%. These results suggest that compound (1) may be used as a potential antiviral and anticancer agent.-
dc.publisherWiley-
dc.titleAntiviral and anticancer activities of 13(E)-labd-13-ene-8α,15-diol isolated from Brachyglottis monroi-
dc.title.alternativeAntiviral and anticancer activities of 13(E)-labd-13-ene-8α,15-diol isolated from Brachyglottis monroi-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number2-
dc.citation.endPage174-
dc.citation.startPage169-
dc.citation.volume24-
dc.contributor.alternativeName최화정-
dc.contributor.alternativeName송재형-
dc.contributor.alternativeName권두한-
dc.contributor.alternativeName백승화-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 24, no. 2, pp. 169-174-
dc.identifier.doi10.1002/ptr.2875-
dc.subject.keyword13(E)-labd-13-ene-8α,15-diol-
dc.subject.keywordAnticancer activity-
dc.subject.keywordAntiviral activity-
dc.subject.keywordBrachyglottis monroi-
dc.subject.keywordHuman rhinovirus-
dc.subject.local13(E)-labd-13-ene-8α,15-diol-
dc.subject.localAnticancer activity-
dc.subject.localAntiviral activity-
dc.subject.localBrachyglottis monroi-
dc.subject.localHuman rhinovirus-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.