Desalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells

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dc.contributor.authorJung-Ran Noh-
dc.contributor.authorGil-Tae Gang-
dc.contributor.authorYong Hoon Kim-
dc.contributor.authorKeum Jin Yang-
dc.contributor.authorChul Ho Lee-
dc.contributor.authorO S Na-
dc.contributor.authorG J Kim-
dc.contributor.authorW K Oh-
dc.contributor.authorY D Lee-
dc.date.accessioned2017-04-19T09:17:28Z-
dc.date.available2017-04-19T09:17:28Z-
dc.date.issued2010-
dc.identifier.issn1976-1457-
dc.identifier.uri10.4162/nrp.2010.4.1.3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9422-
dc.description.abstractThis study was performed to investigate the effect of desalinated underground seawater (named as 'magma seawater', MSW) of Jeju Island in Korea on lipid metabolism and antioxidant activity. MSW was collected from underground of Han-Dong in Jeju Island, and freely given to high fat diet (HFD)-fed C57BL/6 mice for 10 weeks. Although there were no significant differences in the body weight changes and plasma lipid levels, hepatic triglyceride levels were significantly lower in the MSW group than in the normal tap water (TW)-drunken control group. Furthermore, the activity of fatty acid synthase (FAS) was significantly decreased and carnitine palmitoyltransferase (CPT) activity was increased in MSW group compared to TW group. Similarly, real-time PCR analysis revealed that mRNA expressions of lipogenic genes were lowered in MSW groups compared to the control group. In a morphometric observation on the liver tissue, accumulation of fats was remarkably reduced in MSW group. Meanwhile, in vitro assay, free radical scavenging activity measured by using diphenylpicrylhydrazyl (DPPH) was increased in MSW group. The 2'-7'-dichlorofluorescein diacetate (DCF-DA) staining followed with fluorescent microscopy showed a low intensity of fluorescence in MSW-treated HepG2 cells, compared to TW-treated HepG2 cells, which indicated that the production of reactive oxygen species by tert-butyl hydroperoxide (t-BHP) in HepG2 cells was decreased by MSW treatment. The antioxidant effect of MSW on t-BHP-induced oxidative stress in HepG2 cells was supported by the increased activities of intracellular antioxidant enzymes such as catalase and glutathione reductase. From these results, we speculate that MSW has an inhibitory effect on lipogenesis in liver and might play a protective role against cell damage by t-BHP-induced oxidative stress.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDesalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells-
dc.title.alternativeDesalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells-
dc.typeArticle-
dc.citation.titleNutrition Research and Practice-
dc.citation.number1-
dc.citation.endPage10-
dc.citation.startPage3-
dc.citation.volume4-
dc.contributor.affiliatedAuthorJung-Ran Noh-
dc.contributor.affiliatedAuthorGil-Tae Gang-
dc.contributor.affiliatedAuthorYong Hoon Kim-
dc.contributor.affiliatedAuthorKeum Jin Yang-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.alternativeName노정란-
dc.contributor.alternativeName강길태-
dc.contributor.alternativeName김용훈-
dc.contributor.alternativeName양금진-
dc.contributor.alternativeName이철호-
dc.contributor.alternativeName나오수-
dc.contributor.alternativeName김기주-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName이영돈-
dc.identifier.bibliographicCitationNutrition Research and Practice, vol. 4, no. 1, pp. 3-10-
dc.identifier.doi10.4162/nrp.2010.4.1.3-
dc.subject.keywordUnderground seawater-
dc.subject.keywordlipid metabolism-
dc.subject.keywordhepatic lipid-
dc.subject.keywordantioxidant effect-
dc.subject.localUnderground seawater-
dc.subject.locallipid metabolism-
dc.subject.localLipid Metabolism-
dc.subject.localLipid metabolism-
dc.subject.localHepatic lipid-
dc.subject.localhepatic lipid-
dc.subject.localAnti-oxidant effect-
dc.subject.localantioxidant effect-
dc.subject.localAntioxidant effect-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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