A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice

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Title
A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice
Author(s)
S D Lee; Song Kyu Park; E S Lee; Hwan Mook Kim; Chang Woo Lee; Kiho Lee; Ki Hoon Lee; Moorim Kang; K S Lee; J Lee; W I Hwang; D C Kim
Bibliographic Citation
Journal of Medicinal Food, vol. 13, no. 1, pp. 1-5
Publication Year
2010
Abstract
Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0g/kg/day were 18.9% (P<.05), 60.0% (P<.001), and 67.5% (P<.001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.
Keyword
Anticancer effectHuman tumor xenograftLipid-soluble ginseng extractOral administration
ISSN
1096-620X
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/jmf.2009.1142
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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