Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone = 설포닐아미노 칼콘의 미백활성

Cited 72 time in scopus
Metadata Downloads
Title
Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone = 설포닐아미노 칼콘의 미백활성
Author(s)
W D Seo; Young Bae Ryu; M J Curtis-Long; C W Lee; Hyung Won Ryu; K C Jang; K H Park
Bibliographic Citation
European Journal of Medicinal Chemistry, vol. 45, no. 5, pp. 2010-2017
Publication Year
2010
Abstract
The 4′-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both α-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting ability relative to compounds designed to only target tyrosianse activity. TSAHC emerged to be a competitive reversible inhibitor of mushroom tyrosinase. More importantly, it was also able to return the melanin content of α-melanocyte stimulated by α-MSH to base levels unlike other inhibitors that only targeted tyrosinase. The Western blot for expression levels of proteins involved in melanogenesis showed that TSAHC significantly decreased three main tyrosinase related protein in melanin biosynthesis, tyrosinase, TRP-1 and TRP-2.
Keyword
ChalconeDepigmentationSulfonylamino chalconeTyrosinase
ISSN
0223-5234
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejmech.2010.01.049
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.